Similarity Measurement of Neuronal Morphology Based on Convolutional Auto-Encoder and Spatial Registration
Fan Xiayue1&, Zhen Haotian2&, Shang Zengyi2, Xu Wenfei2, Li Zhongyu2*
1(Center for Immunological and Metabolic Diseases, The First Affiliated Hospital of Xi'an Jiaotong University, Xian 710061, China) 2(School of Software Engineering, Xi'an Jiaotong University, Xi'an 710000, China)
Abstract：Morphology of neurons is closely related to their function. With the advancement of neuron tracing technology, more and more high-quality digitally reconstructed 3D neuron morphology data are emerging. A two-step neuron morphology measurement framework, based on deep learning and 3D spatial data registration technology, was proposed for the computational analysis of 3D neuronal structures. Through fast comparison and fine comparison, the framework could be used for the growing volume of neuron morphological data from the whole neuron to the branch. 99 453 neurons from the NeuroMorpho dataset were selected for the experiment. Compared with the existing fine comparison algorithms, this framework was more than 20 times faster with good universality, which could be applied to any neuron morphological data without other prior conditions. For the neurons registered in the brain atlas template, 233 uPNs were selected as the validation data, and 97.39% retrieval accuracy was achieved. For unregistered neurons, three types of neuron data were selected for verification, including 495 glutamatergic neurons, 389 multi-dendritic-dendritic arborization neurons, and 249 pyramidal neurons. The retrieval accuracy reached 91.7%, 93.79% and 83.1% respectively. Our proposed method is expected to be used for neuron type identification and correlation analysis of neuron morphology and characteristics.
樊夏玥, 甄昊天, 商增谊, 徐文菲, 李钟毓. 基于卷积自编码器与点云配准的神经元形态相似性度量方法[J]. 中国生物医学工程学报, 2023, 42(1): 62-73.
Fan Xiayue, Zhen Haotian, Shang Zengyi, Xu Wenfei, Li Zhongyu. Similarity Measurement of Neuronal Morphology Based on Convolutional Auto-Encoder and Spatial Registration. Chinese Journal of Biomedical Engineering, 2023, 42(1): 62-73.
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