纳米药物递送在脑缺血再灌注损伤中对炎症反应和氧化应激的治疗及其进展

doi:10.3969/j.issn.0258-8021.2023.02.012

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摘要脑卒中是世界范围内致死率排第二位的疾病,其中80 %为缺血性脑卒中。再灌注损伤是影响脑缺血预后的关键,包括炎症反应和氧化应激等。近年来,功能化纳米药物递送体系因其良好的生物相容性、高效性、强特异性等优势在脑缺血疾病研究中被广泛应用。综述金属纳米递药体系、生物相容纳米递药体系以及高分子纳米递药体系在脑缺血再灌注损伤中抑制炎症反应以及清除氧化应激的研究,并对纳米药物递送体系今后的发展前景进行展望。

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	肖新芋
	高禹
	蒋宁
	彭奇龄

关键词 ：纳米药物递送, 脑缺血再灌注损伤, 炎症反应, 氧化应激, 高分子纳米颗粒

Abstract：Stroke is the second leading cause of death worldwide, 80 % of which is ischemic stroke. Reperfusion injury including inflammation, oxidative stress etc. is the key to prognosis of cerebral ischemia. Recently, functionalized nano-drug delivery systems,are widely applied in the cerebral ischemia for their characteristics of biocompatibility, tractability, and strong specificity. This paper reviews the research progresses on metal nano-delivery systems, biocompatible nano-delivery systems, and polymer nano-delivery systems that inhibit inflammatory responses and eliminate oxidative stress in the ischemia/reperfusion injury. The future development prospects of nano drug-delivery systems are proposed as well.

Key words： nanomedicine delivery cerebral ischemia-reperfusion injury inflammation oxidative stress polymeric nanoparticle

收稿日期: 2021-10-26

PACS:

R318

基金资助:重庆市自然科学基金(cstc2020jcyj-msxm0218);重庆市教委科技项目(KJQN202000401)

通讯作者: ^*E-mail: pqlpzy@cqmu.edu.cn

引用本文:

肖新芋, 高禹, 蒋宁, 彭奇龄. 纳米药物递送在脑缺血再灌注损伤中对炎症反应和氧化应激的治疗及其进展[J]. 中国生物医学工程学报, 2023, 42(2): 235-241.
Xiao Xinyu, Gao Yu, Jiang Ning, Peng Qiling. Advances and Perspectives of Nano-Drug Delivery Systems Targeting Inflammation and Oxidative Stress during Cerebral Ischemia-Reperfusion Injury. Chinese Journal of Biomedical Engineering, 2023, 42(2): 235-241.

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http://cjbme.csbme.org/CN/10.3969/j.issn.0258-8021.2023.02.012 或 http://cjbme.csbme.org/CN/Y2023/V42/I2/235