Application Progress of Pulsed Electric Field Ablation in the Treatment of Atrial Fibrillation
Zang Lianru1#, Ji Xingkai1, Zhang Hao1, Yan Shengjie1, Wu Xiaomei1,2,3,4,5#*
1(Centre for Biomedical Engineering, School of Information Science and Technology, Fudan University, Shanghai 200438, China) 2(Academy for Engineering and Technology, Fudan University, Shanghai 200433, China) 3(Key Laboratory of Medical Imaging Computing and Computer Assisted Intervention (MICCAI) of Shanghai, Fudan University, Shanghai 200032, China) 4(Shanghai Engineering Research Centre of Assistive Devices, Shanghai 200093, China) 5(Yiwu Research Institute of Fudan University, Yiwu 322000, Zhejiang, China)
Abstract：Atrial fibrillation (AF) is one of the most common arrhythmias in clinical practice, and pulmonary vein isolation of the left atrium is an effective method for treating atrial fibrillation. Pulsed electric field ablation (PFA) is a new ablation technique that uses high voltage and short duration to injure tissue by an irreversible electroporation mechanism. For the application of PFA in the field of AF treatment, firstly, the principle of PFA was introduced; then results of clinical experiments were used to demonstrate the advantages of PFA, including the non-thermal effect that could not only achieve effective myocardial tissue injury but also reduce the risk of injury to adjacent myocardial tissues (such as pulmonary veins, esophagus, phrenic nerves, blood vessels), fast ablation speed, and low contact dependence. The current mainstream PFA systems, the characteristics of ablation catheters corresponding to these systems, and clinical applications were also introduced. Finally, suggestions for the problems to be solved in the application of PFA in the treatment of AF at present were proposed, and perspectives for the future development of this field were provided.
臧连儒, 季星凯, 章颢, 鄢盛杰, 邬小玫. 脉冲电场消融在房颤治疗中的应用进展[J]. 中国生物医学工程学报, 2023, 42(2): 219-228.
Zang Lianru, Ji Xingkai, Zhang Hao, Yan Shengjie, Wu Xiaomei. Application Progress of Pulsed Electric Field Ablation in the Treatment of Atrial Fibrillation. Chinese Journal of Biomedical Engineering, 2023, 42(2): 219-228.
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