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中国生物医学工程学报  2021, Vol. 40 Issue (1): 118-123    DOI: 10.3969/j.issn.0258-8021.2021.01.13
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脱细胞技术在组织工程血管中的应用进展
成津#, 王聪, 谷涌泉*
(首都医科大学宣武医院,北京 100053)
Progress on the Application of Decellularization Techniques in Tissue Engineering Vascular Scaffolds
Cheng Jin#, Wang Cong, Gu Yongquan*
(Xuanwu Hospital, Capital Medical University, Beijing 100053, China)
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摘要 将天然血管经过脱细胞处理得到的脱细胞血管,被认为是一种具有广阔应用前景的组织工程血管支架材料。截至目前,细胞外基质(ECM)支架的制备方法仍缺乏统一标准。脱细胞方法的选择取决于组织来源和基质支架的用途,尤其对于脱细胞血管等需要长期承受血流冲击的基质支架材料来说,脱细胞方案的选择至关重要。细胞清除效率和细胞外基质支架的性能很大程度上取决于选用的脱细胞方法。综述应用于血管的脱细胞方法,包括物理、化学、酶和血清等方法在脱细胞血管制备中的使用,并比较不同脱细胞方法的脱细胞效率和对血管基质的组织结构、力学性能和生物活性等方面的影响,阐明合理制订脱细胞方案的重要性。
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成津
王聪
谷涌泉
关键词 脱细胞细胞外基质血管支架组织工程    
Abstract:The decellularized blood vessel prepared by decellularizing the natural blood vessel is considered as one important kind of tissue engineering vascular scaffolds and has broad application prospects. However, the preparation of extracellular matrix (ECM) still lacks uniform standards. The choice of decellularization methods depends on the tissue source and the application of the ECM. The decellularization protocols used for preparing ECM are very important, especially for the ECM scaffolds such as decellularized blood vessels that need to withstand the blood press for a long time. The maintenance of ECM integrity and cell removal efficiency are highly dependent on the specific approaches used for decellularization. This article reviewed decellularization methods applied to blood vessels, including physical, chemical, enzymatic and serum applications in the preparation of decellularized blood vessels. The decellularization efficiency of different decellularization methods and their effects on the tissue structure, mechanical properties and biological activity of the vascular matrix were compared, and the importance of developing reasonable decellularization protocols was emphasized.
Key wordsdecellularization    extracellular matrix    blood vessel    scaffolds    tissue engineering
收稿日期: 2020-04-02     
PACS:  R318  
基金资助:国家重点研发计划(2017YFC1104100)
通讯作者: *E-mail:Yongquan_Gu@163.com   
作者简介: #中国生物医学工程学会会员
引用本文:   
成津, 王聪, 谷涌泉. 脱细胞技术在组织工程血管中的应用进展[J]. 中国生物医学工程学报, 2021, 40(1): 118-123.
Cheng Jin, Wang Cong, Gu Yongquan. Progress on the Application of Decellularization Techniques in Tissue Engineering Vascular Scaffolds. Chinese Journal of Biomedical Engineering, 2021, 40(1): 118-123.
链接本文:  
http://cjbme.csbme.org/CN/10.3969/j.issn.0258-8021.2021.01.13     或     http://cjbme.csbme.org/CN/Y2021/V40/I1/118
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