Lumen and Media-Adventitia Borders Detection in IVUS Images Using Conditional Generative Adversarial Networks
Yuan Shaofeng1,2, Yang Feng1,2*, Xu Lin3 *, Wu Yangyang1,2, Huang Jing1,2, Liu Yaqin1,2
1.(School of Biomedical Engineering, Southern Medical University, Guangzhou 510515, China) 2.(Guangdong Provincial Key Laboratory of Medical Image Processing, Southern Medical University, Guangzhou 510515, China); 3.(Department of Cardiology, Southern Theater General Hospital (Guangzhou General Hospital of Guangzhou Military Region), PLA, Guangzhou 510010, China)
Abstract：This paper presented an improved method based on stacked hourglass networks (SHGN) and conditional generative adversarial networks (C-GAN) for detecting lumen (LU) and media-adventitia (MA) borders in intravascular ultrasound (IVUS) images to overcome the problems of interference factors, such as different kinds of plaques, ultrasound shadow and branches of vessels. According to the specific shape of coronary artery, several approaches used for data augmentation were applied to increase the number of IVUS samples in training set, including rotating every other 10 degrees, scaling up or down and implementing gamma transformation, in order to reduce the risk of over-fitting during the training stage. Subsequently, in the spirit of adversarial training, a joint loss function based on L1 or L2 loss was constructed and the networks learned a mapping between input IVUS images and their corresponding ground-truths, to segment the whole image into three regions: non-vessel, plaque and lumen regions. Lastly, LU and MA borders were obtained by a thresholding method. Experiments were performed on an international reference dataset containing 435 IVUS images from 10 patients and a small dataset of 100 frames from department of cardiology in Guangzhou General Hospital of Guangzhou Military Region. Quantitative evaluation results showed that the average Jaccard Measures (JM) of two borders of interest were 93% and 95%, the average percentage of area difference measures (PAD) for both was 3%, and average Hausdorff distance measures (HD) were 0.19 mm and 0.16 mm, respectively. These evaluation metrics could meet clinical demands, and the performance of our method was better than those of algorithms evaluated on the same reference dataset and the Pix2Pix model′s performance. Successful detection results on Guangzhou General Hospital dataset demonstrated that the proposed method has good generalization on cross-dataset.
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