The Effect of Calcium Phosphate Scaffold on Angiogenesis
Tan Yanlin1&, Luo Chunyuan2&, Chen Kairui3, Zhang Qiang1*, Xiong Bokai1,Liu Xiupiao1, Yang Peipei1, Yang Yuchen1
1(Department of Oral & Maxillofacial Surgery, First Affiliated Hospital of Nanchang University, Nanchang 330006, China) 2(Laboratory of Oral Science, Stomatological Hospital of Guangzhou Medical University, Guangzhou 510140, China) 3(Department of Oral & Maxillofacial Surgery,Guangzhou Women and Children Center, Guangzhou 510140, China)
Abstract：Angiogenesis in scaffold materials can increase the volume of osteogenesis and the success rate of bone product transplantation, therefore is one crucial condition for bone tissue formation. Researches of vascular networks in scaffold materials or induce angiogenesis in osteogenesis by scaffold materials have been intensively conducted woldwide. Calcium phosphate is the most commonly used scaffold material in bone tissue engineering research. Studies have demonstrated that it can be given good bone conduction and osteoinductivity through structural optimization, but the application research of calcium phosphate scaffold has not fully realized its angiogenesis meaning. This article reviewed the effects of calcium phosphate scaffolds on angiogenesis and addressed the importance of angiogenesis in bone tissue engineering.
谭艳林, 罗春媛, 陈凯瑞, 张强, 熊博凯, 刘秀飘, 杨佩佩, 杨羽晨. 磷酸钙支架材料促血管生成影响的研究[J]. 中国生物医学工程学报, 2019, 38(4): 498-502.
Tan Yanlin, Luo Chunyuan, Chen Kairui, Zhang Qiang, Xiong Bokai,Liu Xiupiao, Yang Peipei, Yang Yuchen. The Effect of Calcium Phosphate Scaffold on Angiogenesis. Chinese Journal of Biomedical Engineering, 2019, 38(4): 498-502.
[1] Wyskida K, Wajda J, Klein D, et al. Nutrient intake assessed with diet history questionnaire II, in relation to long-term calcium-phosphate control in hemodialysis patients with end-stage renal failure[J]. Advances in Clinical & Experimental Medicine, 2018, 27(2):217-224. [2] Xiao Fei, Wang Chuandong, Wang Chenglong, et al. BMPER enhances bone formation by promoting the osteogenesis-angiogenesis coupling process in mesenchymal stem cells[J]. Cellular Physiology & Biochemistry, 2018, 45(5):1927-1939. [3] Schell H, Schulz N, Hoff P, et al. Inflammatory phase of bone healing initiates the regenerative healing cascade[J]. Cell and Tissue Research, 2012, 347(3):567-573. [4] Brennan MA, Renaud A, Guilloton F, et al. Inferior in vivo osteogenesis and superior angiogenesis of human adipose-derived stem cells compared with bone marrow-derived stem cells cultured in xeno-free conditions[J]. Stem Cells Transl Med, 2017,6:2160-2172. [5] Parry J, Dadsetan M, Bravo D, et al. VEGF-mediated angiogenesis and vascularization of a fumarate-crosslinked polycaprolactone (PCLF) scaffold [J]. Connective Tissue Research, 2018, 59(6):542-549. [6] Shi Mengchao, Xia Lunguo, Chen Zetao, et al. Europium-doped mesoporous silica nanosphere as an immune-modulating osteogenesis/angiogenesis agent[J]. Biomaterials, 2017, 144:176-187. [7] Ding Hao, Chen Song, Song Wenqi, et al. Dimethyloxaloylglycine improves angiogenic activity of bone marrow stromal cells in the tissue-engineered bone[J]. International Journal of Biological Sciences, 2014, 10(7):746-756. [8] Ogose A, Kondo N, Umezu H, et al. Histological assessment in grafts of highly purified beta-tricalcium phosphate (OSferion) in human bones[J]. Biomaterials, 2006, 27(8):1542-1549. [9] Henry J, Burugapalli K, Neuenschwander P, et al. Structural variants of biodegradable polyesterurethane in vivo evoke a cellular and angiogenic response that is dictated by architecture[J]. Acta Biomaterialia, 2009, 5(1):29-42. [10] Karageorgiou V, Kaplan D, Porosity of 3D biomaterial scaffolds and osteogenesis[J]. Biomaterials, 2005, 26(27):5474-5491. [11] Bai Feng, Wang Zhen, Lu Jianxi, et al. The correlation between the internal structure and vascularization of controllable porous bioceramic materials in vivo: a quantitative study[J]. Tissue engineering. Part A, 2010, 16(12):3791-3803. [12] Xiao Xin, Wang Wei, Liu Dong, et al. The promotion of angiogenesis induced by three-dimensional porous beta-tricalcium phosphate scaffold with different interconnection sizes via activation of PI3K/Akt pathways[J]. Scientific Reports, 2015, 5:9409. [13] Mohamedali A, Avolio A, Baker M, Mechanical stretch: Physiological and pathological implications for human vascular endothelial cells[J]. Vascular Cell, 2015, 7:8. [14] Sandino C, Checa S, Prendergast PJ. et al. Simulation of angiogenesis and cell differentiation in a CaP scaffold subjected to compressive strains using a lattice modeling approach[J]. Biomaterials, 2010, 31(8):2446-2452. [15] König M, Stock C, Wiesinger A, et al. High phosphate directly affects endothelial function by downregulating annexin II[J]. Kidney International, 2013, 83(2):213-222. [16] Black C, Goriainov V, Gibbs D, et al. Bone tissue engineering[J]. Current Molecular Biology Reports, 2015, 1(3):132-140. [17] Xu Xiang, Hu Jianzhong, Lu Hongbin, Histological observation of a gelatin sponge transplant loaded with bone marrow-derived mesenchymal stem cells combined with platelet-rich plasma in repairing an annulus dfect[J]. PLoS ONE, 2017, 12(2):e0171500. [18] Xiu Jintao, Fan Junjun, Li Jie, et al. Different angiogenic abilities of self-setting calcium phosphate cement scaffolds consisting of different proportions of fibrin glue.%A Xiu J[J]. BioMed Research International, 2014, 2014: 785146. [19] Das A, Fishero B, Christophel J, et al. Poly(lactic-co-glycolide) polymer constructs cross-linked with human BMP-6 and VEGF protein significantly enhance rat mandible defect repair[J]. Cell & Tissue Research, 2015, 364(1):1-11. [20] Borysova L, Calcium signalling in pericytes[J]. Journal of Vascular Research, 2014, 51(3):190-199. [21] Montjovent M, Liu Y, Wismeijer D, et al. VEGF incorporated into calcium phosphate ceramics promotes vascularisation and bone formation in vivo[J]. European Cells & Materials, 2010, 19:30-40. [22] Choi EJ, Oh S, Kim S, The effect of covalently immobilized FGF-2 on biphasic calcium phosphate bone substitute on enhanced biological compatibility and activity[J]. BioMed Research International, 2015, 2015: 742192. [23] Yoshida M, Kawakami M, Okada M, et al. The effects of bone morphogenetic protein and basic fibroblast growth factor on cultured mesenchymal stem cells for spine fusion[J]. Spine, 2007, 32(10):1067-1071. [24] Fu Weili, Xiang Zhou Huang, Fuguo, et al. Coculture of peripheral blood-derived mesenchymal stem cells and endothelial progenitor cells on strontium-doped calcium polyphosphate scaffolds to generate vascularized engineered bone[J]. Tissue Engineering Part A, 2015, 21:948-959. [25] Gbureck U, Habibovic P, Vorndran E, et al. Angiogenesis in calcium phosphate scaffolds by inorganic copper ion release[J]. Tissue Engineeing Part A, 2009, 15(7):1601-1609. [26] Zhang Wenjie, Chang Qing, Xu Ling, et al. Graphene oxide-copper nanocomposite-coated porous CaP scaffold for vascularized bone regeneration via activation of Hif-1α[J]. Advanced Healthcare Materials, 2016, 5(11):1299-1309. [27] Yang Pei, Huang Xin, Shen Jacson, et al. Development of a new pre-vascularized tissue-engineered construct using pre-differentiated rADSCs, arteriovenous vascular bundle and porous nano-hydroxyapatide-polyamide 66 scaffold[J]. BMC Musculoskeletal Disorders, 2013, 14:318. [28] Folkman J, Mechanochemical switching between growth and differentiation during fibroblast growth factor-stimulated angiogenesis in vitro: role of extracellular matrix[J]. The Journal of Cell Biology, 1989, 109(1):317-330. [29] Chae J, Buehler M, Hunter C, et al. Cyclic tensile strain triggers a sequence of autocrine and paracrine signaling to regulate angiogenic sprouting in human vascular cells[J]. Proceedings of the National Academy of Sciences of the United States of America, 2009, 106(36):15279-15284. [30] Etiennemanneville S, Hall A, A Rho GTPases in cell biology[J]. Nature, 2002, 420(6916):629-635. [31] Chow S, Sun M, Qin L, et al. Low-intensity pulsed ultrasound accelerated callus formation, angiogenesis and callus remodeling in osteoporotic fracture healing[J]. Ultrasound in Medicine & Biology, 2011, 37(2):231-238.
