Advances in Polymeric Biomaterial Scaffolds for Islet Transplantation
Liao Shibo1, Huang Shuyu1*, Xi Tingfei2, Wu Min1, Zou Yi1, Li Ling1, Zhu Zhao1
1Department of Endocrinology, Xiaogan Hospital Affiliated to Wuhan University of Science and Technology, Xiaogan 432000, Hubei, China; 2Shenzhen Key Laboratory of Human Tissue Regeneration and Repair, Shenzhen Institute, Peking University, Shenzhen 518057, Guangdong, China
Abstract：The liver may not be an optimal environment for islet transplantation. Problems associated with the hepatic transplantation of islets may preclude the broad application of islet transplantation. Many parts of the body have been tested as alternatives for the intrahepatic transplantation sites. Up to now, none of these sites provided ideal environments for pancreatic islets. Therefore, creating a extrahepatic transplantation site for islets through exploiting biological engineered material scaffolds become a preferred option. In this paper, the research progress on polymeric biomaterial scaffolds for islet transplantation in the last three years were reviewed, including natural polymer scaffolds, synthetic polymer scaffolds, synthetic-natural composite scaffolds, whole organ decellularized scaffolds and three-dimensional bioprinting scaffolds. The prospects was proposed and discussed as well.
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