Abstract：Poly(vinyl amine) (PVAm) is a water soluble macromolecule containing the highest primary amine groups among all amino polymers. PVAm is featured by its polycation property, pH-responsive behaviour and high reactive activity, and has various applications in biomedical science, petrochemical engineering, paper manufacturing, textile printing, and wastewater treatment. In this work, the research progress on the applications of PVAm and its derivatives in biomedical engineering was reviewed and the research results produced in recent ten years in the fields of gene transfection, drug therapy and tissue engineering were summarized. The advantages and disadvantages of PVAm and its derivatives in these fields were comparatively analyzed and the development tendency in these technology areas was presented, which could provide forward guidance for the design and synthesis of PVAm derivatives and the exploration of their applications in biomedical engineering.
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