Exosomes and Their Applications in Tissue Engineering
Liu Yufei1, Zhang Zhiling2, Wang Yanying2, Dong Yunsheng1, Zhang Lin1, Wang Shufang1*
1(Key Laboratory of Bioactive Material Materials for Ministry of Education, College of Life Sciences, Nankai University, Tianjin 300071, China) 2(Tianjin Stomatology Hospital, Nankai University, Tianjin 300350, China)
Abstract：Mesenchymal stem cells are adult stem cells with self-renewal ability, which are widely found in tissues such as bone marrow, adipose tissue, and peripheral blood. Mesenchymal stem cells have many therapeutic effects in the clinic currently, which brings hope for the cure of many diseases. Recent studies have shown that mesenchymal stem cells release many kinds of small molecular substances, among them, exosomes carrying large amounts of biologically active factors can mediate communication between cells and play a role in physiological and pathological processes. As a research hotspot of cell-free tissue engineering in recent years, exosomes have contributed to solutions in clinical applications of regenerative medicine to some extent, such as seed cell source, quantity and immune rejection, and at the same time in disease diagnosis and treatment. This paper introduces the methods of exosome extraction and identification and its potential application in tissue engineering and discusses its future development.
刘语菲, 张智玲, 王艳颖, 董云生, 张琳, 王淑芳. 外泌体及其在组织工程中的应用[J]. 中国生物医学工程学报, 2020, 39(1): 109-113.
Liu Yufei, Zhang Zhiling, Wang Yanying, Dong Yunsheng, Zhang Lin, Wang Shufang. Exosomes and Their Applications in Tissue Engineering. Chinese Journal of Biomedical Engineering, 2020, 39(1): 109-113.
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