Abstract：Plasma medicine is an emerging field focusing on the application of plasma in medicine. In this review, we provided a brief overview of the low-temperature atmospheric-pressure plasma (LT-APP) first, and then focused on the application of LT-APP in oncology. In oncological application, direct plasma treatment to tumor cells can induce the apoptosis, necrosis and autophagy by generating large amounts of reactive agents; Plasma can also kill the cancer cells indirectly via the cytotoxicity of plasma activated liquids. On the other hand, plasma also has several non-fatal effects on tumors as well. In addition, plasma plays an important role in the field of anti-cancer drugs by participating in the construction of sustained-release systems of chemotherapeutic drugs, assisting drug transportation, and having a synergistic anti-tumor effect with traditional chemotherapeutic drugs.
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