Abstract：This work is aimed to establish a resting functional network based on EEG signals to investigate effects of DC galvanic vestibular stimulation (GVS) with different intensities on the connectivity of resting functional network to reveal the mechanism of vestibular DC stimulation regulating vestibular dysfunction from the perspective of EEG connectivity and topology. 30 subjects were selected, and the experimental group was given 0.5, 1, 2 mA by vestibular direct current, and sham stimulation was applied to the control group to collect resting EEG signals before and after the stimulation with different current intensities. The Pearson correlation coefficient method was used to construct the correlation matrix. A brain network topology connection diagram with a threshold value of 0.44 was constructed to investigate the brain network topology attributes within the threshold value range of 0.44~0.84, and the impact of GVS of 0.5, 1, 2 mA on the brain network was explored. Compared with applying false stimulation, the effect of 1 mA vestibular electrical stimulation exerted the most significant effect. The clustering coefficient, node degree, global efficiency, and characteristic path length of the brain network after sham stimulation were 0.309 ± 0.023, 10.760 ± 1.502, 0.296 ± 0.014, 0.547 ± 0.018, and the clustering coefficient, node degree, global efficiency, and characteristic path length of the brain network after 1 mA vestibular electrical stimulation were 0.296 ± 0.014, 0.299 ± 0.014, 0.301 ± 0.014, and 0.299 ± 0.012, respectively (P<0.05). In conclusion, vestibular direct current stimulation was able to change the brain network connection and the brain network topology attribute of the brain. The GVS of 0.5, 1, 2 mA improved the efficiency of information transmission between the brain regions and the speed of information transmission and enhanced the strength of functional connection. Among them, the GVS stimulation of 1 mA exerted the most significant effect. This study provided a new idea for effective intervention of brain functional network activities in the treatment of vestibular diseases.
耿跃华, 李超然, 徐桂芝. 前庭直流电刺激对脑电静息态功能网络的影响[J]. 中国生物医学工程学报, 2023, 42(5): 520-528.
Geng Yuehua, Li Chaoran, Xu Guizhi. Effect of Direct Current Gavalnic Vestibular Stimulation on Resting State Functional Network of EEG. Chinese Journal of Biomedical Engineering, 2023, 42(5): 520-528.
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