Study on Executive Control Function and Brain Network inHigh Trait Anxiety Individuals
Ji Shumei1,2*, Bu Xinxin1,2, Xun Xingmiao1,2, Su Xinle1,2, Xu Quansheng1,2
1(Institute of Health Technology, Yanshan University,Qinhuangdao 066004, Hebei, China) 2(Institute of Biomedical Engineering, School of Electrical Engineering, Yanshan University, Qinghuangdao 066004, Hebei, China)
摘要利用行为学及复杂网络分析方法,探讨高特质焦虑(HTA)个体执行控制功能及其脑功能网络特点。以16名HTA个体为研究对象、16名低特质焦虑(LTA)个体为对照,进行Simon空间认知冲突任务,同步记录行为数据(反应时间及正确率)及 64导脑电(EEG)信号。对EEG数据进行同步似然分析,选择合适阈值构建脑网络拓扑结构并计算网络整体属性参数及节点属性参数。利用方差分析方法,对两组被试的行为数据及脑网络属性参数进行统计学分析,结果显示, HTA组被试的冲突反应时间显著长于LTA组(641.29±72.11 vs 602.10±61.47, P< 0.05)、反应正确率显著低于LTA组(90.73±2.14 vs 95.62±1.52, P< 0.05),表明其认知冲突反应的效率降低、执行控制功能下降。对beta节律脑网络的分析显示:HTA组被试其额顶叶各节点的节点度值均显著小于LTA组(P< 0.05),聚类系数(0.5341±0.0813 vs 0.6243±0.0527)及全局效率(0.0142±0.0037 vs 0.0185±0.0023)均显著小于LTA组(P< 0.05),而特征路径长度显著大于LTA组(1.8057±0.0036 vs 1.4380±0.0117, P< 0.05);高gamma节律脑网络的各属性参数结果与beta节律相似。以上结果表明HTA个体冲突监控、冲突解决等执行控制能力下降, 其机制不仅与额顶执行控制网络功能受损有关,也与脑网络的整合功能及信息传输能力减弱有关。额顶执行控制网络功能受损、执行控制能力下降可能是HTA个体稳定、固有的特征。
Abstract：By using behavioral and complex network analysis methods, this study explored the executive control function and brain network characteristics of high trait anxiety (HTA) individuals. Sixteen HTA individuals (as subjects) and sixteen low trait anxiety (LTA) individuals (as controls) were asked to perform Simon spatial conflict task, while behavioral data (response time and accuracy rate) and 64-channel EEG signals were recorded simultaneously. The EEG data were analyzed by synchronous likelihood analysis, and the appropriate threshold value was selected to construct the brain network topology. The overall attribute parameters and node attribute parameters of the network were calculated. The behavior data and the attribute parameters of brain network were analyzed by ANOVA. Results showed that the conflict response time of HTA group was significantly longer than that of LTA group (641.29±72.11 vs 602.10±61.47, P< 0.05), and the response accuracy rate was significantly lower than that of LTA group (90.73±2.14 vs 95.62±1.52, P< 0.05). These results indicated that the efficiency of cognitive conflict response and their executive control ability decreased. Analysis of the brain network in beta rhythm showed that the frontal and parietal node degree of HTA group was significantly less than that of LTA group (P< 0.05), the clustering coefficient (0.5341±0.0813 vs 0.6243±0.0527) and global efficiency (0.0142±0.0037 vs 0.0185±0.0023) was significantly smaller than that of LTA group (P< 0.05), while the characteristic path length was significantly larger than that of LTA group (1.8057±0.0036 vs 1.4380±0.0117, P< 0.05). The results of high gamma rhythmic brain network were like those of beta rhythm. These results suggest that the execution control ability of conflict monitoring and conflict resolution in HTA individuals is reduced. The underlying mechanism is not only related to the impaired function of thefrontal-parietal execution control network, but also related to the weakening of the integration function and information transmission capacity of the brain network. Impaired function offrontal-parietal executive control network and decreased executive control ability are stable and inherent characteristics of HTA individuals.
季淑梅, 步鑫鑫, 荀兴苗, 苏新乐, 许全盛. 高特质焦虑个体执行控制功能及其脑网络研究[J]. 中国生物医学工程学报, 2021, 40(3): 272-279.
Ji Shumei, Bu Xinxin, Xun Xingmiao, Su Xinle, Xu Quansheng. Study on Executive Control Function and Brain Network inHigh Trait Anxiety Individuals. Chinese Journal of Biomedical Engineering, 2021, 40(3): 272-279.
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