Abstract：Mechanical loading is an important regulatory factor for bone mass and structure. Bone remodeling and formation are closely associated to metabolism. It is considered that electromechanical property of bone is a link between bone remodeling and mechanical loading, therefore, the streaming potential is one important direction in the electromechanical property of bone. The objective of this study is to confirm the difference of the produced streaming potential from buffer solution flowing through Haversian canal and bone canalicules by experiments. The streaming potential of eight bone specimens under five different loading rates was measured using selfdesigned testing system. The lateral surface of bone specimen was sealed by silicone rubber to simulate the flowing situation of buffer solution flowing through Haversian canal; while unsealed condition was used to simulate the situation of buffer solution flowing through Haversian canal and bone canalicules of osteon whose specimen surface was split at the same time. Result showed that corresponding to loading rates of 26, 36, 60, 180 and 360 kPa/s, when the lateral surface was sealed, the stable values of streaming potential respectively were (0.29±0.09），（0.24±0.06），（0.21±0.05），（0.19±0.05）and（0.16±0.04）mV. Under unsealed condition, the streaming potential was (069±008）,（0.61±0.09）,（0.57±0.07）,（0.51±0.05）and（0.46±0.05）mV, which was apparently higher than that under sealed condition (P < 0.05). Besides, the difference between the potentials reflects that the produced streaming potential when the buffer solution was flowing through bone canalicules was higher than that when the buffer solution was flowing through Haversian canal. Based on the microstructure of bone and in consideration of bone cells are mainly distributed near the bone canalicules, the experimental results provide the basis for study of streaming potential and bone remodeling.
王轶涵 徐莲云* 富东慧 侯振德. 骨内微管中流动电位的实验研究[J]. 中国生物医学工程学报, 2013, 32(6): 649-654.
WANG Yi Han XU Lian Yun* FU Dong Hui HOU ZhenDe . An Experimental Study on the Behavior of Streaming Potentials in Bone Microchannels. journal1, 2013, 32(6): 649-654.
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