脂肪干细胞在软骨组织工程中的研究进展

doi:10.3969/j.issn.0258-8021. 2014. 04.012

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摘要近年来脂肪干细胞（ADSC）的成软骨潜能备受瞩目，其作为种子细胞在软骨组织工程应用方面前景广阔，然而目前并没有一种高效的诱导方法被世界公认。外源性生长因子、基因修饰、共培养、生长因子与共培养联合、支架材料等多种手段均可诱导ADSC向软骨细胞方向分化，但各方法的优劣，诱导分化时的信号通路及新生软骨的性状并未见详细的分析和讨论。文中介绍了以上多种诱导方法的研究现状及问题，并讨论了化学因素、供体年龄、组织获取部位等对其的影响，以期为ADSC的临床应用提供一定的理论参考。

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	赵明璨刘畅^*

关键词 ：软骨组织工程, 脂肪干细胞, 生长因子, 共培养, 支架材料

Abstract：The potential for adiposederived stem cells (ADSCs) of differentiating into chondrocytes has attracted increasing attentions in recent years. As seed cells, ADSCs have broad prospects in the use of cartilage tissue engineering. However, methods to obtain high quality cells are still lack and have
not been recognized in the world. Although various methods such as exogenous growth factors, genetic modification, coculture, growth factors ally with coculture, and scaffold materials can induce the differentiation of ADSCs into chondrocytes, the pros and cons of each method, signaling pathways of differentiation and traits of neochondrocytes are not clear in detail. This paper introduced the status and problems of multiple methods mentioned above, and discussed the influence of the chemical factors, donor age, organizations to get parts etc. on the cell culture, aiming to provide a theoretical reference for the clinical application of ADSCs.

Key words： cartilage tissue engineering adipose derived stem cells growth factors coculture scaffold materials

引用本文:

赵明璨刘畅^*. 脂肪干细胞在软骨组织工程中的研究进展[J]. 中国生物医学工程学报, 2014, 33(4): 475-481.
ZHAO Ming Can LIU Chang^*. Research Progress on AdiposeDerived Stem Cells in Cartilage Tissue Engineering. journal1, 2014, 33(4): 475-481.

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http://cjbme.csbme.org/CN/10.3969/j.issn.0258-8021. 2014. 04.012 或 http://cjbme.csbme.org/CN/Y2014/V33/I4/475

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