Abstract：Organ-on-a-chip is an emerging in vitro biological model with great prospects in biomedical researches. However, its development is often limited by the cumbersome and expensive fabrication process. Recently, researchers have adopted 3D printing technology into the fabrication and therefore made this process simpler and less expensive. Besides, this strategy also increased the complexity of chip structure and allowed the one-step fabrication. 3D printing technology has strongly promoted organ-on-a-chip related researches and contributed to its wide application. This paper reviewed the research status of 3D printing technology in the fabrication of organ-on-a-chip, including the development background of organ-on-a-chip, limitations of traditional fabrication methods, the technical classification and biomedical applications of 3D printing technology.Five 3D printing methods were listed based on different forming principles, and their characteristics and applications in chip fabrication were compared as well. Besides, the applications of 3D printing technology in the construction of liver, kidney, blood vessel, heart and other organs-on-chips were also discussed. Finally, we concluded with our thoughts on the challenges and future perspectives of this technology.
刘妍, 杨清振, 陈小明, 谷方伟, 张辉. 3D打印技术制备器官芯片的研究现状[J]. 中国生物医学工程学报, 2020, 39(1): 97-108.
Liu Yan, Yang Qingzhen, Chen Xiaoming, Gu Fangwei, Zhang Hui. Fabrication of Organ-on-a-Chip by 3D Printing Technology. Chinese Journal of Biomedical Engineering, 2020, 39(1): 97-108.
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