Abstract：To investigate the synchronization of human bilateral cortical spontaneous activities in language areas and the relationship between the synchronization and language ability, optical brain imaging was used to measure resting state cortical activities in language areas of subjects with different language ability. The measured signals included temporal fluctuations of oxygenated and deoxygenatedhemoglobin. Three groups of subjects participated in the experiment, including 25 children with autism, 11 normal children and 20 normal adults. Fortyfour optical channels were used in the experiment to record the spontaneous fluctuations for 8 minutes from bilateral inferior and temporal cortices. After the recorded signals were filtered and processed to remove the global systemic interference, the temporal correlation coefficient was calculated for each channel pair located symmetrically on the left and the right hemisphere. This correlation coefficient reflects the synchronization of activities arising from cortical regions right beneath the channel pair. The average interhemispheric correlation coefficients for the symmetric regions of interest (e.g., inferior frontal cortex, temporal cortex) were also calculated and quantitatively compared between the three groups of subjects. Our data show the average interhemispheric correlations for temporal language cortices are different between subject groups: the correlation for children with autism (r=0.306±0.039) is significantly (P=0.048) lower than that for normal children (r=0.472±0.037), normal children is significantly (P=0.00058) lower than normal adults (r=0.639±0.020), and adult males (r=0.604±0.035) is slightly lower than adult females (r=0.673±0.017), but not significantly (P >0.05). These results imply optical brain imaging may provide qualitative and quantitative evaluation on the functioning of human brain language network.
李军*邱丽娜 朱绘霖 朱志方. 光学脑成像检测静息态下双侧语言皮层活动的同步性[J]. 中国生物医学工程学报, 2014, 33(4): 410-417.
LI Jun* QIU Li Na ZHU Hui Lin ZHU Zhi Fang. Synchronization of Resting State Bilateral Cortical Activities in Language Areas Measured with Optical Brain Imaging. journal1, 2014, 33(4): 410-417.
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