Research Progress of Degradable Behavior of Absorbable Biomaterials in Bone Repair
Ma Jing1,2, Su Xiuyun1, Tang Bin2, Wang Lin1,3*, Pei Guoxian1,3*
1(Southern University of Science and Technology Hospital, Shenzhen 518055, Guangdong, China) 2(Department of Biomedical Engineering, Southern University of Science and Technology, Shenzhen 518055, Guangdong, China) 3(School of Medicine, Southern University of Science and Technology, Shenzhen 518055, Guangdong, China)
Abstract：Degradable orthopedic implants have attracted intensive attention of clinicians and researchers because the application of these implants can avoid the secondary surgery for implant removal after bone repair and the problem of inflammation of permanent implants. However, the inherent properties of biomaterials of the implants, such as degradation rate, mechanical strength, and osteogenic ability, may hinder their clinical translational applications. To solve the bottleneck, many efforts have been made to the regulation of the degradation behavior and osteogenic capacity of biomaterials via coating bioactive materials, optimizing crystal structure or porous structure and doping functional small molecules. Based on the latest research literatures, this review focused on the degradation mechanism of the degradable biomaterials (including metals, ceramics, natural polymers, and synthetic polymers), the regulation methods of their degradation behavior as well as the effects on their mechanical properties and ability of bone regeneration, aiming to provide a comprehensive reference for developing novel biodegradable orthopedic implants whose degradation behavior depend on the formation of new bone.
马静, 苏秀云, 唐斌, 王林, 裴国献. 骨修复中可吸收材料降解行为的研究进展[J]. 中国生物医学工程学报, 2023, 42(5): 626-635.
Ma Jing, Su Xiuyun, Tang Bin, Wang Lin, Pei Guoxian. Research Progress of Degradable Behavior of Absorbable Biomaterials in Bone Repair. Chinese Journal of Biomedical Engineering, 2023, 42(5): 626-635.
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