The Mechanism and Applications of Cryoablation for Tumor
Chen Mu, Liu Wei, Liu Baolin*
(Institute of Biothermal and Technology, School of Health Science and Engineering, University of Shanghai for Science and Technology, Shanghai 200093, China)
Abstract：Cryoablation is a non-invasive tumor therapy which carry out repeated freeze-thaw cycles with the aid of refrigerant (eg.nitrogen and helium), causing damage to the tumor tissues by ice crystals formation, microcirculation injury, apoptosis and cryo-immunologic response. In recent years, cryoablation has become an important treatment method for many types of tumors due to its less invasiveness, high targeting property and good visualization of the ice ball in cryotherapy. However, cryoablation still faces many difficulties, such as causing several kinds of complications and the freezing boundary is difficult to control. This paper reviewed the mechanism, technical features, application status, main advantages and disadvantages and development trend of cryoablation. At the same time, how to improve the complications of cryoablation by optimizing the freeze-thaw program and combining immunotherapy were also discussed. The challenges facing the complete ablation of large tumors were prospected and summarized.
陈目, 刘威, 刘宝林. 肿瘤冷冻消融术的作用机理及应用[J]. 中国生物医学工程学报, 2023, 42(6): 757-768.
Chen Mu, Liu Wei, Liu Baolin. The Mechanism and Applications of Cryoablation for Tumor. Chinese Journal of Biomedical Engineering, 2023, 42(6): 757-768.
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