微针介导的浅表肿瘤治疗研究进展

doi:10.3969/j.issn.0258-8021.2021.03.09

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摘要作为一种新兴的给药方式,微针透皮给药具有微创无痛、安全高效、使用方便及改善患者依从性等优点。在浅表肿瘤治疗中,微针可以有效刺穿皮肤角质层,将负载的药物高效传递并富集于肿瘤部位,从而避免肝脏首过效应,防止胃肠道副作用,可极大地提高药物的利用率。在相同剂量下,相对于静脉注射给药及肿瘤内注射给药,微针透皮给药表现出更好的治疗效果。综述近年来微针结合化学疗法、光热疗法、光动力疗法、基因疗法、免疫疗法等在浅表肿瘤治疗中的研究进展,对于未来开创微创、局部精准给药、高效开展浅表肿瘤治疗具有指导意义。

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	宋高
	刘天琦
	张雪雅
	童再再
	江国华

关键词 ：微针, 透皮给药, 浅表肿瘤

Abstract：As a new emerging approach, microneedle-based transdermal delivery system has the advantages of minimal invasion, painlessness, safety, efficiency, convenient usage and improvement of patient compliance. In the treatment of superficial tumors, microneedles can effectively pierce the stratum corneum of the skin, thereby promoting the loaded-drug to be penetrated and enriched on the tumor sites. The application of microneedles can have the drugs to avoid the clearance by the liver due to the first pass effect, prevent gastrointestinal side effects, and improve the utilization rate, exhibiting better therapeutic effect in comparison with intravenous administration and intratumoral injection under the same drug dose level. Combined with the new therapeutic strategies, including chemotherapy, photothermal therapy, photodynamic therapy, gene therapy and immunotherapy, the research progresses of microneedles for treatment on superficial tumors have been reviewed in this paper, aiming to promote the therapies of superficial tumors with minimally invasive and local precision drug delivery in the future.

Key words： microneedles transdermal administration superficial tumor

收稿日期: 2020-06-15

PACS:

R318

基金资助:国家自然科学基金(51873194);浙江省自然科学基金(LY18E030006)

通讯作者: * E-mail: ghjiang_cn@zstu.edu.cn

引用本文:

宋高, 刘天琦, 张雪雅, 童再再, 江国华. 微针介导的浅表肿瘤治疗研究进展[J]. 中国生物医学工程学报, 2021, 40(3): 330-343.
Song Gao, Liu Tianqi, Zhang Xueya, Tong Zaizai, Jiang Guohua. Advances in Microneedle-Mediated Therapies for Superficial Tumors. Chinese Journal of Biomedical Engineering, 2021, 40(3): 330-343.

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http://cjbme.csbme.org/CN/10.3969/j.issn.0258-8021.2021.03.09 或 http://cjbme.csbme.org/CN/Y2021/V40/I3/330

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