微针介导的浅表肿瘤治疗研究进展
宋高1,2 , 刘天琦1,2 , 张雪雅1,2 , 童再再1,2,3 , 江国华1,2,3*
1 (浙江理工大学材料科学与工程学院高分子材料系,杭州 310018)2 (浙江理工大学智能生物材料研究所,杭州 310018)3 (浙江-毛里求斯生物医用材料与组织工程联合中心,杭州 310018)
Advances in Microneedle-Mediated Therapies for Superficial Tumors
Song Gao1,2 , Liu Tianqi1,2 , Zhang Xueya1,2 , Tong Zaizai1,2,3 , Jiang Guohua1,2,3*
1 (Department of Polymer Materials, College of Materials Science and Engineering, Zhejiang Sci-Tech University, Hangzhou 310018, China)2 (Institute of Smart Biomaterials, Zhejiang Sci-Tech University, Hangzhou 310018, China)3 (Zhejiang Mauritius Joint Research Center for Biomaterials and Tissue Engineering, Zhejiang Sci-Tech University, Hangzhou 310018, China)
摘要 作为一种新兴的给药方式,微针透皮给药具有微创无痛、安全高效、使用方便及改善患者依从性等优点。在浅表肿瘤治疗中,微针可以有效刺穿皮肤角质层,将负载的药物高效传递并富集于肿瘤部位,从而避免肝脏首过效应,防止胃肠道副作用,可极大地提高药物的利用率。在相同剂量下,相对于静脉注射给药及肿瘤内注射给药,微针透皮给药表现出更好的治疗效果。综述近年来微针结合化学疗法、光热疗法、光动力疗法、基因疗法、免疫疗法等在浅表肿瘤治疗中的研究进展,对于未来开创微创、局部精准给药、高效开展浅表肿瘤治疗具有指导意义。
关键词 ：
微针 ,
透皮给药 ,
浅表肿瘤
Abstract ：As a new emerging approach, microneedle-based transdermal delivery system has the advantages of minimal invasion, painlessness, safety, efficiency, convenient usage and improvement of patient compliance. In the treatment of superficial tumors, microneedles can effectively pierce the stratum corneum of the skin, thereby promoting the loaded-drug to be penetrated and enriched on the tumor sites. The application of microneedles can have the drugs to avoid the clearance by the liver due to the first pass effect, prevent gastrointestinal side effects, and improve the utilization rate, exhibiting better therapeutic effect in comparison with intravenous administration and intratumoral injection under the same drug dose level. Combined with the new therapeutic strategies, including chemotherapy, photothermal therapy, photodynamic therapy, gene therapy and immunotherapy, the research progresses of microneedles for treatment on superficial tumors have been reviewed in this paper, aiming to promote the therapies of superficial tumors with minimally invasive and local precision drug delivery in the future.
Key words ：
microneedles
transdermal administration
superficial tumor
收稿日期: 2020-06-15
基金资助: 国家自然科学基金(51873194);浙江省自然科学基金(LY18E030006)
通讯作者:
* E-mail: ghjiang_cn@zstu.edu.cn
引用本文:
宋高, 刘天琦, 张雪雅, 童再再, 江国华. 微针介导的浅表肿瘤治疗研究进展[J]. 中国生物医学工程学报, 2021, 40(3): 330-343.
链接本文:
http://cjbme.csbme.org/CN/10.3969/j.issn.0258-8021.2021.03.09 或 http://cjbme.csbme.org/CN/Y2021/V40/I3/330
[1] Rogers HW, Weinstock MA, Harris AR, et al. Incidence estimate of nonmelanoma skin cancer in the United States, 2006[J]. Arch Dermatol, 2010, 146(3): 283-287.18 O49 -TPZ nanoparticles for simultaneous hypoxia-activated chemotherapy and photothermal therapy[J]. ACS Appl Mater Interfaces, 2018, 10(4): 3405-3413.ex vivo [J]. Int J Biol Macromol, 2019, 154(1): 1265-1275.2 O2 -Responsive mesoporous silica nanoparticles integrated with microneedle patches for the glucose-monitored transdermal delivery of insulin[J]. J Mater Chem B, 2017, 5(41): 8200-8208.2 O2 -responsive polymeric vesicles integrated with microneedle patches for glucose-sensitive transcutaneous delivery of insulin in diabetic rats[J]. ACS Appl Mater Interfaces, 2018, 10: 20014-20024.2 for NIR-triggered transdermal delivery on diabetic rats[J]. ACS Appl Bio Mater, 2018, 1: 1906-1917.© microneedles-mediated transdermal delivery of doxorubicin and celecoxib co-loaded liposomes for enhancing the anticancer effect[J]. Mater Sci Eng C, 2019, 99: 1448-1458.2 ‐based nanoagent to enhance chemodynamic therapy[J]. Angewandte Chemie, 2018, 57(18): 4902-4906.2 O2 sequentially triggered chemodynamic therapy[J]. J Am Chem Soc, 2019, 141(2): 849-857.
