交联对氧化纤维素/蚕丝蛋白复合膜结构和性能的影响

doi:10.3969/j.issn.0258-8021.2015. 02.012

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摘要本研究的目的是探讨交联剂对纳米细菌纤维素/蚕丝蛋白复合物的理化性能的影响。一种方法是将细菌纤维素膜和氧化的细菌纤维素膜分别与蚕丝蛋白溶液直接混合；另一种方法是两者混合时加入交联剂。对复合膜进行傅里叶变换红外光谱（FTIR）、核磁共振光谱（NMR）、X射线光电子能谱(XPS)、场发射扫描电镜（FESEM）和力学强度测试分析。FTIR、NMR等结果表明蚕丝蛋白能结合在氧化的细菌纤维素膜上,XPS表明无论是否加交联剂，C1s、O1s和N1s能谱峰没有显著不同。BC/SF复合膜，未加交联剂的C/N摩尔比与加交联剂的C/N摩尔比相比较，从963减到394，而TBC/SF的C/N比从503增到741。FESEM表明加入交联剂组的膜表面比较平整，结构有明显改变，力学强度测试表明未加交联剂TBC/SF和加交联剂TBC/SF的断裂伸长率比较，有显著性差异（P＜001）。通过添加交联剂所制得的复合膜的性能更好，并且在医用材料方面尤其在细胞化的血管支架方面的应用有一定的前景。

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	王甩艳¹黄涛¹赖琛²奚廷斐¹
	2#* 南方¹

关键词 ：细菌纤维素, 氧化, 蚕丝蛋白, 复合

Abstract：The purpose of this study is to investigate two kinds of preparation methods on nanobacterial cellulose/silk fibroin composites and to compare the physical and chemical properties of the resulting composite products. One method is to mix directly bacterial cellulose or oxidized bacterial cellulose membranes with silk fibroin solution. Another one is to add crosslinking agents during the mixing process. The composite products were characterized using Fourier transforminfrared (FTIR) spectroscopy,13C NMR spectrum, Xray photoelectron spectroscopy (XPS), field emission scanning electron microscopy (FESEM) and mechanical testing. Results show that fibroin can successfully be combined on the oxidized bacterial cellulose membrane, XPS results show that no matter adding crosslinking agents or not, C1s, O1s and N1s appeared no difference. BC/SF composite membrane, the comparison C/N molar ratio of without crosslinking agents and with them, reduced from 963 to 394, while the TBC/SF, C/N ratio increased from 503 to 741. The membrane surface of one group containing crosslinking agents is smoother than another, and the structure has obvious changes. There are significant differences in elongation at break of TBC/SF (P＜001). Based on this work, the performance of composite films prepared by adding crosslinking agents is better, and the materials described here demonstrate the potential in medical material applications, especially in a cellular vascular graft filed.

Key words： bacterial cellulose oxidation silk fibroin composite

基金资助:国家科技支撑计划（2012BAI18B06）

引用本文:

王甩艳¹黄涛¹赖琛²奚廷斐^1,2#*南方¹. 交联对氧化纤维素/蚕丝蛋白复合膜结构和性能的影响[J]. 中国生物医学工程学报, 2015, 34(2): 212-220.
Wang Shuaiyan¹Huang Tao¹Lai Chen² Xi Tingfei^1,2#*Nan Fang¹. The Effect of Crosslink on the Structures and Performance of Oxidized Bacterial Cellulose/Silk Fibroin Composite Films. journal1, 2015, 34(2): 212-220.

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http://cjbme.csbme.org/CN/10.3969/j.issn.0258-8021.2015. 02.012 或 http://cjbme.csbme.org/CN/Y2015/V34/I2/212