血管内光声成像的研究进展

doi:10.3969/j.issn.0258-8021. 2015.02.013

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摘要血管内光声（IVPA）成像是近年来发展起来的一种微创血管内成像技术，结合了光声信号激发阶段光吸收较高的对比度和光声信号发射阶段超声检测较高的分辨率，根据斑块成分对光的吸收差异检测和区分动脉粥样硬化斑块，可对斑块的形态和成分做更为全面的了解。介绍IVPA成像系统的研究现状、血管内超声(IVUS)/IVPA组合成像导管的设计与改进，以及在光谱成像、热成像、分子成像和对冠状动脉支架成像方面的应用现状，指出目前存在的问题，并对未来的研究进行展望。

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	孙正^*苑园王健健

关键词 ：动脉粥样硬化, 血管内光声（IVPA）成像, 光谱IVPA, 分子成像, 成像导管

Abstract：Intravascular photoacoustic (IVPA) imaging is a newly developed interventional imaging modality to detect and distinguish atherosclerotic plaques based on the differences between the optical absorption characteristics of different plaque tissues. It combines the contrast of optical absorption with the spatial resolution of ultrasound for deep imaging to obtain comprehensive information of morphology and component of atherosclerotic plaques. In this paper, the progress of IVPA imaging system as well as its applications in spectroscopy imaging, thermal imaging, molecular imaging and coronary stent imaging was reviewed. The current development of integrated IVPA/IVUS imaging catheter is then summarized. The existing problems and future directions in the design and implement IVPA system were also discussed.

Key words： atherosclerotic intravascular photoacoustic (IVPA) spectroscopy IVPA molecular imaging imaging catheter

基金资助:国家自然科学基金（60973087，61372042）；中央高校基本科研业务费专项资金资助（2014ZD31）

引用本文:

孙正^*苑园王健健. 血管内光声成像的研究进展[J]. 中国生物医学工程学报, 2015, 34(2): 221-228.
Sun Zheng^* Yuan Yuan Wang Jiangjiang. Progress of Intravascular Photoacoustic Imaging. journal1, 2015, 34(2): 221-228.

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［1］Go AS, Mozaffarian D, Roger VL, et al. Heart disease and stroke statistics-2014 update: a report from the american heart association ［J］. Circulation, 2014, 129:e28-e292.［2］Naghavi M, Libby P, Falk E, et al. From vulnerable plaque to vulnerable patient: a call for new definitions and risk assessment strategies: part 1 ［J］. Circulation, 2003, :1771-1778.
［3］Bourantas CV, GarciaGarcia HM, Naka KK, et al. Hybrid intravascular imaging: current applications and prospective potential in the study of coronary atherosclerosis ［J］. Journal of the American College of Cardiology, 2013, 61(13):1369-1378.
［4］何军锋，谭毅. 光声成像技术在生物医学中的研究进展［J］. 激光学报, 2007, 5:530-536.
［5］Wang Lihong. Biomedical optics: principles and imaging ［M］// Wang Lihong. Photoacoustic Tomography.New Jersey: John Wiley and Sons, 2007:283-321.
［6］Scherzer O. Handbook of mathematical methods in imaging ［M］// Kuchment P, Kunyansky L. Mathematics of Thermoacoustic and Photoacoustic Tomography. New York: Springer, 2011:817-865.
［7］张雄斐. 光声成像中的伪影及噪声去除研究［D］. 西安: 西安电子科技大学，2012.
［8］Jiao Shuliang, Jiang Minshan, Hu Jianming, et al. Photoacoustic ophthalmoscopy for in vivo retinal imaging ［J］. Optics Express, 2010, 18(4):3967-3972.
［9］Meng Jing, Song Liang. Biomedical photoacoustics in China ［J］. Photoacoustics, 2013, 1(2):43-48.
［10］Wang Bo, Su JL, Karpiouk AB, et al. Intravascular photoacoustic imaging ［J］. IEEE Journal of Selected Topics in Quantum Electronics, 2010, 16(3):588-599.
［11］Sethuraman S, Aglyamov SR, Amirian JH, et al. Intravascular photoacoustic imaging using an IVUS imaging catheter ［J］. IEEE Transactions on Ultrasonics,Ferroelectrics,and Frequency Control, 2007, 54(5):978-986.
［12］王振华，单健，陈铀，等. 激光对生物组织的热损伤机理研究及临床应用探讨［J］. 激光杂志, 2003, 24(1):60-62.
［13］于坤，尹立强. 超声测温技术及应用［J］. 机械与电子, 2010, 13:87.
［14］Sethuraman S, Rakalin A, Aglyamov S, et al. Temperature monitoring in intravascular photoacoustic imaging ［C］ //Yuhas MP,eds. 2006 IEEE Ultrasonics Symposium Proceedings. Piscataway: IEEE Press, 2006:714-717.
［15］Welch AJ. The thermal response of laser irradiated,tissue ［J］. IEEE Journal of Quantum Electronics, 1984,
20(12):1471-1481.
［16］Wang Bo, Emelianov S. Thermal intravascular photoacoustic imaging ［J］. Optical Society of America, 2011, 2(11): 3072-3078.
［17］Sethuraman S. Combined intravascular ultrasound and photoacoustic imaging ［D］. Austin: The University of Texas at Austin, 2007.
［18］Allen TJ, Beard PC. Photoacoustic characterisation of vascular tissue at NIR wavelengths ［C］ //Oraevsky AA, Wang LV,eds. Proceedings of SPIE Photons Plus Ultrasound: Imaging and Sensing. Bellingham: SPIE, 2009:0A-1-0A-9.
［19］Sethuraman S, Wang Bo, Litovsky S, et al. Spectroscopic intravascular photoacoustic imaging ［C］ //Yuhas MP, eds. 2007 IEEE Ultrasonics Symposium Proceedings. Piscataway: IEEE Press, 2007:1188-1191.
［20］Jansen K, Van Der Steen AFW, Van Beusekom HMM, et al. Automatic lipid detection in human coronary atherosclerosis using spectroscopic intravascular photoacoustic imaging ［C］// 2012 IEEE International Ultrasonics Symposium Proceedings. Piscataway: IEEE Press, 2012:32-35.
［21］Wang Bo, Su J, Amirian J, et al. On the possibility to detect lipid in atherosclerotic plaques using intravascular photoacoustic imaging ［C］ //Chon K, Hudson D, eds. IEEE Engineering in Medicine and Biology Society Proceedings. Piscataway: IEEE Press, 2009:4767-4770.
［22］Jansen K, Wu M, Van Der Steen AFW, et al. Photoacoustic imaging of human coronary atherosclerosis in two spectral bands ［J］. Photoacoustics, 2014, 2(1):12-20.
［23］张飞, 石开虎,尹邦良. 血管滋养血管及血管内皮生长因子与动脉粥样硬化斑块研究进展［J］. 心血管病学进展, 2010, 31(6):889-893.
［24］Su JL, Wang Bo, Emelianov SY. Spectroscopic intravascular photoacoustic imaging of neovasculature: phantom studies ［C］ //Oraevsky AA, Wang LV, eds. Proceedings of SPIE Photons Plus Ultrasound: Imaging and Sensing. Bellingham: SPIE, 2009:27-1-27-7.
［25］Libby P. Inflammation in atherosclerosis ［J］. Nature, 2002, 420:868-874.
［26］West JL, Halas NJ. Engineered nanomaterials for biophotonics applications:improving sensing,imaging,and therapeutics ［J］. Annual Review of Biomedical Engineering, 2003, 5:285-292.
［27］Wang Bo, Yantsen E, Larson T, et al. Plasmonic intravascular photoacoustic imaging for detection of macrophages in atherosclerotic plaques ［J］. American Chemical Society, 2008, 9(6):2212-2217.
［28］Wang Bo, Yantsen E, Sokolov K, et al. High sensitivity intravascular photoacoustic imaging of macrophages ［C］ //Oraevsky AA, Wang LV, ds. Proceedings of SPIE Photons Plus Ultrasound: Imaging and Sensing. Bellingham: SPIE, 2009:0V-1-0V-6.
［29］Yeager D, Chen Yunsheng, Litovsky S, et al. Intravascular photoacoustics for imageguidance and temperature monitoring during plasmonic photothermal therapy of atherosclerotic plaques: a feasibility study ［J］. Theranostics, 2014, 4(1):36-46.
［30］Qu Min, Mehrmohammadi M, Truby R, et al. Contrastenhanced magnetophotoacoustic imaging in vivo using dualcontrast nanoparticles ［J］. Photoacoustics, 2014, 2(2):55-62.
［31］Barlis P, Dimopoulos K, Tanigawa J, et al. Quantitative analysis of intracoronary optical coherence tomography measurements of stent strut apposition and tissue coverage ［J］. International Journal of Cardiology, 2010, 141(2):151-156.
［32］彭珏, 覃正笛, 刁现芬, 等. 医学超声关键技术研究和进展 (一)超声换能器与超声编码技术［J］. 生物医学工程学进展, 2013, 34(1):21-27.
［33］Wang Bo, Karpiouk A, Emelianov S. Design of catheter for combined intravascular photoacoustic and ultrasound imaging ［C］ //Waters KR,eds. 2008 IEEE International Ultrasonics Symposium Proceedings. Piscataway: IEEE Press, 2008:1150-1153.
［34］Jansen K, Springeling G, Lancée C, et al. An intravascular photoacoustic imaging catheter ［C］ //2010 IEEE International Ultrasonics Symposium Proceedings. Piscataway: IEEE Press, 2010:378-381.
［35］Bai Xiaosong, Gong Xiaojing, Hau W, et al. Intravascular opticalresolution photoacoustic tomography with a 11 mm diameter catheter ［J］. PLoS ONE, 2014, 9(3):e92463.
［36］Hsieh BY, Chen Sungliang, Ling Tao, et al. Integrated intravascular ultrasound and photoacoustic imaging scan head ［J］. Optics Letters, 2010, 35(17):2892-2894.
［37］Jansen K, Van Soest G, Van Dersteen AFW. Intravascular photoacoustic imaging: a new tool for vulnerable plaque identification ［J］. Ultrasound in Medicine and Biology, 2014, 40(6):1037-1048.
［38］Hsieh BY, Chen Sungliang, Ling Tao, et al. Alloptical transducer for ultrasound and photoacoustic imaging by dichroic filtering ［C］ //2012 IEEE International Ultrasonics Symposium Proceedings, Piscataway: IEEE Press, 2012:1410-1413.
［39］Hsieh BY, Chen Sungliang, Ling Tao, et al. Alloptical scanhead for ultrasound and photoacoustic imagingImagingmode switching by dichroic filtering ［J］. Photoacoustics, 2014, 2(1):39-46.
［40］Sethuraman S, Aglyamov SR, Amirian JH, et al. Development of a combined intravascular ultrasound and photoacoustic imaging system ［C］ //Oraevsky AA, Wang LV, eds. Proceedings of SPIE Photons Plus Ultrasound: Imaging and Sensing. Bellingham: SPIE, 2006:0F-1-0F-10.
［41］王君琳, 孟晓辉, 肖灵. 超声内镜换能器的应用进展［J］. 应用声学, 2013, 32(4):271-276.
［42］谷怀民, 杨思华, 向良忠. 光声成像及其在生物医学中的应用［J］. 生物化学及生物物理进展, 2006, 33(5):431-437.