A Simulation Study Applied to Evaluation of Body Surface Potential Mapping in Ventricular Ectopic Pacemaker Separation and Influence of Lead Density
Hu Xiaogang1, Li Xinya2, Peng Yi2#*
1(School of Electrical Engineering, Beijing Jitotong University, Beijing 100044, China) 2(Institute of Basic Medical Sciences Chinese Academy of Medical Sciences, School of Basic Medicine Peking Union Medical College, Beijing 100005, China)
Abstract：Based on our constructed whole heart electrophysiological model, a simulation study was performed to evaluate body surface potential mapping (BSPM) in the ventricular ectopic pacemaker separation and the influence of lead density. 24 ventricular ectopic pacemakers were selected located in the area of the Purkinje fibers, among them 18 in a horizontal ventricular section within the region of 12.5 mm×16 mm and 6 in a vertical line with the length of 7.5 mm. For each ectopic pacemaker in the same region, correlation coefficients of QRS integral map of BSPM (BSPMQRS ) between itself and every other ones were calculated. The two selected ventricular ectopic pacemakers were considered to be separable if the correlation coefficient was less than a threshold of 0.95. Lead density was reduced by evenly deleting the columns or rows in the lead array under the condition that the remaining leads covering the same area as the original ones. Using the method of statistical inverse deduction, the values of the whole leads were estimated based on the potentials on the leads with lower density. And the correlation coefficients between the estimated potentials and the simulated ones were calculated. The resolutions for ventricular ectopic pacemaker separation with lower lead density were evaluated as well. Results showed that the resolution for horizontal ventricular section was (2.80±0.62) mm. And the resolution for the vertical line was (3.25±0.39) mm. When the lead numbers were changed from the original 252 to 132, 72 and 36, the correlation coefficients of the estimated potentials and the simulated ones were 0.987±0.050,0.946±0.060 and 0.852±0.080, respectively. At the same time, resolution of separating ventricular ectopic pacemakers decreased with the reduction of lead density. In addition to proving the validation of our constructed model, the usability tests provide delighting information about the influence of lead density on the performance of BSPM.
胡小刚, 李心雅, 彭屹. 体表电位标测图进行心室异位起搏点定位之分辨率及导联密度影响的仿真研究[J]. 中国生物医学工程学报, 2016, 35(3): 310-316.
Hu Xiaogang, Li Xinya, Peng Yi. A Simulation Study Applied to Evaluation of Body Surface Potential Mapping in Ventricular Ectopic Pacemaker Separation and Influence of Lead Density. Chinese Journal of Biomedical Engineering, 2016, 35(3): 310-316.
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