Abstract：Despite the significant challenges presented by the complex pathological processes of tumors, the rapid development of nanotechnology provides new solutions. Iron oxide nanoparticle-based nanocomposites have shown enormous potential in the realm of tumor diagnostics and therapy, effectively employed in applications such as magnetic resonance imaging, targeted drug delivery, magnetically activated mechanical therapy, and magnetic hyperthermia therapy. This paper systematically reviewed and outlined the advancements in the preparation methods of iron oxide nanoparticles, encapsulation, and applications in tumor diagnostics and therapy. Researchers have employed various synthesis methods and modification strategies to fabricate iron oxide nanomaterials with diverse sizes, shapes, and surface properties. By integrating these characteristics, researchers can analyze their impact on targeting, drug delivery efficiency, circulation time in vivo, imaging quality, and biocompatibility. Rational design of iron oxide nanoparticle-based nanocomposites facilitates the combined use of multimodal imaging and diversified therapeutic modalities, enhancing the effectiveness of tumor diagnostics and treatment while also accelerating the clinical translation of these composite materials.
杜凯, 张卓玲, 李婷华, 饶微. 氧化铁纳米颗粒的制备方法及其在肿瘤诊疗中的应用[J]. 中国生物医学工程学报, 2025, 44(2): 241-256.
Du Kai, Zhang Zhuoling, Li Tinghua, Rao Wei. Iron Oxide Nanoparticle: Preparation and Application in Tumor Diagnosis and Treatment. Chinese Journal of Biomedical Engineering, 2025, 44(2): 241-256.
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