Abstract：Hydrogels are highly biocompatible biomaterials composed of crosslinked three-dimensional networks of hydrophilic polymers, which can be structurally and functionally designed to modulate their physicochemical properties and thus have a wide range of biomedical application potential. Among them, hydrogels with adhesion ability are widely used as medical tissue adhesives in wound repair of skin, muscle, nerve, bone, cornea, organs and blood vessels due to their ability to mimic physiological environment, excellent biocompatibility, outstanding mechanical properties and most importantly - strong adhesion to tissues. In this paper, we introduced the current state of research on hydrogel adhesives, providing a comprehensive overview of their adhesion mechanisms to tissues, fundamental design principles, associated characteristics, and application contexts, with particular emphasis on their use in cardiac and vascular repair. Additionally, the limitations of existing hydrogel adhesive applications and anticipates future advancements were analyzed, aiming to offer a valuable reference for their clinical application in surgical settings.
陈诗翰, 凡杰夫, 陆清声. 水凝胶粘合剂在心脏和血管修复领域的研究现状[J]. 中国生物医学工程学报, 2025, 44(2): 232-240.
Chen Shihan, Fan Jiefu, Lu Qingsheng. Current Research on Hydrogel Adhesives for Cardiac and Vascular Repair. Chinese Journal of Biomedical Engineering, 2025, 44(2): 232-240.
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