Evaluation of Rehabilitation Status of Patients with Chronic Ischemic Stroke Based onQuantitative EEG
Li Cenbo1, Chen Long1*, Gu Bin2, Wang Zhongpeng2, Zhang Xin1, Ming Dong1,2#
1(Academy of Medical Engineering and Translational Medicine, Tianjin University, Tianjin 300072, China) 2(College of Precision Instrumental and Optoelectronic Engineering, Tianjin University, Tianjin 300072, China)
摘要康复评估可帮助临床医师了解患者的康复情况,合理制定康复训练方案,提高康复治疗效率。而传统康复评估方法无法及时反应患者的康复情况,实现对患者的动态评估,从而降低了卒中患者康复治疗的效率。为此,本研究引入了定量脑电图(qEEG)这一客观康复评估方法,其具有采集方便,反馈迅速的优点,能快速反映卒中患者的康复情况,弥补传统康复评估方法的不足。共招募了28例慢性缺血性卒中患者,采集患者的脑电数据并计算功率比指数、脑对称性指数和相位同步指数,通过斯皮尔曼相关系数分析这些qEEG与改良barthel指数量表和Fugl-Meyer Motor Assessment(FMA)上肢运动部分之间的相关性。研究结果显示,改良barthel指数量表与使用全局导联的β频段IH-PSI相较于其他qEEG相关性最强,相关系数ρ=0.70,显著性P=0.000 2<0.01,具有统计学意义。FMA上肢运动部分与使用C3、C4、FC3、FC4等4个导联的β频段C3FC3C4FC4-PSI相较于其他qEEG相关性最强,相关系数ρ=0.71,显著性P=0.000 09<0.01,具有统计学意义。综上,使用全局导联的β频段IH-PSI结合改良barthel指数量表,使用局部导联的β频段C3FC3C4FC4-PSI结合FMA上肢运动部分有望实现对慢性缺血性卒中患者动态评估,进而提高卒中患者康复治疗的效率。
Abstract：Rehabilitation assessment can help clinicians to understand patients rehabilitation situation, formulate a reasonable rehabilitation training plan, and improve the efficiency of rehabilitation treatment. However, the traditional rehabilitation evaluation methods cannot timely reflect and dynamically evaluate the rehabilitation situation, which would reduce the efficiency of the rehabilitation treatment of stroke patients. In order to solve the above problems, quantitative electroencephalogram (qEEG), an objective rehabilitation evaluation method, was introduced in this study, which has the advantages of convenient collection and rapid feedback, and can quickly reflect the rehabilitation situation of stroke patients and make up for the shortcomings of traditional rehabilitation assessment methods. In this study, 28 patients with chronic ischemic stroke were enrolled. The EEG data of the patients were collected and thepower ratio index, Brain symmetry index andphase synchrony index were calculated, and Spelman correlation coefficient was used to analyze the correlation between the above-mentioned qEEG and the modified barthel index and the upper extremity motor section of the Fugl-Meyer motor assessment (FMA). The results showed that there was a significant positive correlation between the modified barthel index and the IH-PSI in the β band of the global channel (ρ=0.70 P=0.000 2). The correlation between the modified barthel index and the IH-PSI in the β band of the global channel was the strongest compared with the other qEEG, the correlation coefficient was ρ = 0.70, and P=0.000 2<0.01, which was statistically significant. The correlation between the upper extremity motor section of the FMA and the C3FC3C4FC4-PSI in the β band using four channels of C3, C4, FC3, FC4 was the strongest compared with the other qEEG, the correlation coefficient was ρ=0.71, and P=0.000 09<0.01, which was statistically significant. In summary, the use of the IH-PSI in the β band of the global channel combined with the modified barthel index, the use of the C3FC3C4FC4-PSI in the β band using four channels of C3, C4, FC3, FC4 combined with the upper extremity motor section of the FMA was expected to achieve dynamic assessment of patients with chronic ischemic stroke, and improved the efficiency of rehabilitation treatment for stroke patients.
李岑博, 陈龙, 顾斌, 王仲朋, 张鑫, 明东. 定量脑电图用于慢性缺血性卒中患者康复状态评估[J]. 中国生物医学工程学报, 2022, 41(5): 547-557.
Li Cenbo,Chen Long*,Gu Bin,Wang Zhongpeng,Zhang Xin,Ming Dong,#. Evaluation of Rehabilitation Status of Patients with Chronic Ischemic Stroke Based onQuantitative EEG. Chinese Journal of Biomedical Engineering, 2022, 41(5): 547-557.
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