Study on the Brain Function Network of Transcranial Direct Current Stimulation Intervention on Working Memory
Lu Sheng1, Luo Zhizeng1*, Shi Hongfei2, Gao Yunyuan1
1(Institute of Intelligent Control and Robotics,School of Automation,Hangzhou Dianzi University, Hangzhou 310018, China) 2(The Fourth Affiliated Hospital of Medical College of Zhejiang University, Jinhua 322000, Zhejiang,China)
Abstract：Working memory is an important basis of advanced cognitive function. In order to explore the effect of transcranial direct current stimulation on working memory and its specific mechanism, 18 subjects were recruited to participate in the experiment. The behavioral data (accuracy, reaction time) and EEG signals of subjects in the memory load task of three-picture, four-picture and five-picture after stimulation of sham/anode/cathode tDCS were collected. Firstly, the working memory ability was evaluated based on behavioral data. Then, the correlation of EEG signals between different channels was used to construct the brain functional network in each state, and the network characteristic parameters such as average degree(D), average clustering coefficient(C) and global efficiency(E) are calculated. Finally, the changes of behavior data and network characteristic parameters in three kind of memory load tasks after different tDCS stimulation are analyzed. It was shown that compared with sham tDCS(four-picture: 81.25%±2.30%;five- picture: 73.25%±5.36%), the accuracy of the four-picture and five-picture load tasks after anode tDCS (four-picture: 89.75%±1.36%;five- picture: 78.50%±2.25%) were significantly improved (P<0.05), but the behavior data after cathodic tDCS was irregular. According to the change of the characteristic parameters of brain functional network, the height value nodes after anode stimulation were mainly distributed in the stimulation point F3 and the surrounding area. The average degree, average clustering coefficient and global efficiency of the three kinds of memory load tasks were significantly increased compared with those after sham stimulation (P<0.05). The increase of the above three parameters in the four-picture task was the largest (sham tDCS:D=10.55±2.31,C=0.60±0.07,E=0.26±0.03; anodal tDCS: D=15.37±1.35,C=0.71±0.04,E=0.34±0.02). The height value nodes after cathode stimulation were mainly distributed in the right frontal lobe and occipital lobe. Only in the five-picture load task(sham tDCS:D=13.73±2.42, C=0.64±0.07,E=0.31±0.04;cathode tDCS:D=11.46±2.31,C=0.58±0.05,E=0.28±0.03), the average degree, average clustering coefficient and global efficiency are significantly reduced(P<0.05). The results showed that anode tDCS could effectively improve working memory performance by activating the activity of left dorsolateral prefrontal cortex, and the enhancement effect was more significant in the moderate difficulty task; cathode tDCS inhibited the activity of the cortex and reduce the connectivity of the brain, but the brain chose other brain regions for functional compensation, which showed great individual differences, and the inhibition effect was more significant in high difficulty tasks.
陆晟, 罗志增, 史红斐, 高云圆. 经颅直流电刺激干预工作记忆的脑功能网络研究[J]. 中国生物医学工程学报, 2021, 40(2): 145-153.
Lu Sheng, Luo Zhizeng, Shi Hongfei, Gao Yunyuan. Study on the Brain Function Network of Transcranial Direct Current Stimulation Intervention on Working Memory. Chinese Journal of Biomedical Engineering, 2021, 40(2): 145-153.
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