经颅直流电刺激调控大脑认知功能的研究进展

doi:10.3969/j.issn.0258-8021.2018.02.011

摘要
图/表
参考文献(73)
相关文章 (2)

全文: PDF (809 KB) HTML (1 KB)
输出: BibTeX | EndNote (RIS)

摘要经颅直流电刺激是一种非侵入式调节大脑皮层神经元活动的技术,其利用的直流电强度较低且恒定(0.5~2 mA),持续时间一般为5～30 min。近年来,经颅直流电刺激以其成本低、便携性强、调控效果突出等特点,在神经科学和神经病理学等领域得到大量的研究和应用。介绍经颅直流电刺激的生理效应和实施方式,并分别从学习和记忆、注意力、感知、情绪和决策等方面,论述经颅直流电刺激应用于大脑认知功能调控的研究现状和发展趋势。

	服务

	把本文推荐给朋友
	加入我的书架
	加入引用管理器
	E-mail Alert
	RSS
	作者相关文章
	周鹏
	魏晋文
	孙畅
	綦宏志
	明东

关键词 ：经颅直流电刺激, 神经调控, 大脑认知

Abstract：Transcranial direct current stimulation (tDCS) is a noninvasive technique that regulates neuronal activity in the cerebral cortex by using constant and low intensity direct current (0.5-2 mA) with duration of typically 5 to 30 minutes. Due to its low cost, high portability and excellent regulation effects, in recent years, transcranial direct current stimulation has been widely studied and applied in the fields of neuroscience and neuropathology. This paper introduced its physiological effects and approaches of implementation, and discussed the current research status and development trend of tDCS applied to the regulation of cognitive functions in the aspects of learning and memory, attention, perception, emotion and decision.

Key words： transcranial direct current stimulation(tDCS) neuromudulation cognition

收稿日期: 2017-04-10

PACS:

R318

基金资助:国家自然科学基金 (51377120); 天津市自然基金(13JCQNJC13900)

通讯作者: zpzpa@vip.sina.com

引用本文:

周鹏, 魏晋文, 孙畅, 綦宏志, 明东. 经颅直流电刺激调控大脑认知功能的研究进展[J]. 中国生物医学工程学报, 2018, 37(2): 208-214.
Zhou Peng, Wei Jinwen, Sun Chang, Qi Hongzhi, Ming Dong. Research Advancements in the Regulation of Transcranial Direct Current Stimulation (tDCS) for Cerebral Cognitive Function. Chinese Journal of Biomedical Engineering, 2018, 37(2): 208-214.

链接本文:

http://cjbme.csbme.org/CN/10.3969/j.issn.0258-8021.2018.02.011 或 http://cjbme.csbme.org/CN/Y2018/V37/I2/208

[1] Brunoni AR, Nitsche MA, Bolognini N, et al. Clinical research with transcranial direct current stimulation (tDCS): challenges and future directions [J]. Brain Stimul, 2012, 5(3): 175-195.
[2] He Bin, Baxter B, Edelman BJ, et al. Noninvasive brain-computer interfaces based on sensorimotor rhythms [J]. Proc IEEE, 2015, 103(6): 907-925.
[3] Priori A, Berardelli A, Rona S, et al. Polarization of the human motor cortex through the scalp [J]. Neuroreport, 1998, 9(10): 2257-2260.
[4] Nitsche MA, Paulus W. Excitability changes induced in the human motor cortex by weak transcranial direct current stimulation [J]. J Physiol, 2000, 527(3): 633-639.
[5] Coffman BA, Clark VP, Parasuraman R. Battery powered thought: Enhancement of attention, learning, and memory in healthy adults using transcranial direct current stimulation [J]. Neuroimage, 2014, 85(2):895-908.
[6] Bindman LJ, Lippold OCJ, Redfearn JWT. Long-lasting changes in the level of the electrical activity of the cerebral cortex produced by polarizing currents [J]. Nature, 1962, 196(4854):584-585.
[7] Purpura DP, Urpura, Mcmurtry JG. Intracellular activities and evoked potential changes during polarization of motor cortex [J]. J Neurophysiol, 1965, 28(28): 166-185.
[8] Filmer HL, Dux PE, Mattingley JB. Applications of transcranial direct current stimulation for understanding brain function [J]. Trends Neurosci, 2014, 37(12): 742-753.
[9] Woods AJ, Antal A, Bikson M, et al. A technical guide to tDCS, and related non-invasive brain stimulation tools [J]. Clinical Neurophysiology, 2016, 127(2): 1031-1046.
[10] Horvath JC, Forte JD, Carter O. Evidence that transcranial direct current stimulation (tDCS) generates little-to-no reliable neurophysiologic effect beyond MEP amplitude modulation in healthy human subjects: A systematic review [J]. Neuropsychologia, 2015, 66:213-236.
[11] Bestmann S, Berker AO, Bonaiuto J. Understanding the behavioural consequences of noninvasive brain stimulation [J]. Trends Cogn Sci, 2015, 19(1): 13-20.
[12] Parkin BL, Ekhtiari H, Walsh VF. Non-invasive human brain stimulation in cognitive neuroscience: A primer [J]. Neuron, 2015, 87(5):932-945.
[13] Batsikadze G, Moliadze V, Paulus W, et al. Partially non-linear stimulation intensity-dependent effects of direct current stimulation on motor cortex excitability in humans [J]. J Physiol, 2013,591(7): 1987-2000.
[14] Liebetanz D, Nitsche MA, Tergau F, et al. Pharmacological approach to the mechanisms of transcranial DC-stimulation-induced after-effects of human motor cortex excitability [J]. Brain, 2002, 125(10): 2238-2247.
[15] Nitsche MA, Fricke K, Henschke U, et al. Pharmacological modulation of cortical excitability shifts induced by transcranial direct current stimulation in humans [J]. J Physiol, 2003, 553(1): 293-301.
[16] Stagg CJ, Best JG, Stephenson MC, et al. Polarity-sensitive modulation of cortical neurotransmitters by transcranial stimulation [J]. J Neurosci, 2009, 29(16): 5202-5206.
[17] Monai H, Ohkura M, Tanaka M, et al. Calcium imaging reveals glial involvement in transcranial direct current stimulation-induced plasticity in mouse brain [J]. Nature Communications, 2016, 7(11100):11100.
[18] Roche N, Lackmy A, Achache V, et al. Effects of anodal transcranial direct current stimulation over the leg motor area on lumbar spinal network excitability in healthy subjects [J]. Journal of Physiology, 2011, 589(11):2813-2826.
[19] Grefkes C, Fink GR. Reorganization of cerebral networks after stroke: new insights from neuroimaging with connectivity approaches [J]. Brain A Journal of Neurology, 2011, 134(5):1264-1276.
[20] Brunoni AR, Vanderhasselt MA. Working memory improvement with non-invasive brain stimulation of the dorsolateral prefrontal cortex: a systematic review and meta-analysis [J]. Brain & Cognition, 2014, 86(86):1-9.
[21] Fregni F, Boggio PS, Nitsche M, et al. Anodal transcranial direct current stimulation of prefrontal cortex enhances working memory [J]. Exp Brain Res, 2005, 166(1): 23-30.
[22] Andrews SC, Hoy KE, Enticott PG, et al. Improving working memory: the effect of combining cognitive activity and anodal transcranial direct current stimulation to the left dorsolateral prefrontal cortex [J]. Brain Stimul, 2011, 4(2): 84-89.
[23] Hill AT, Fitzgerald PB, Hoy KE. Effects of anodal transcranial direct current stimulation on working memory: A systematic review and meta-analysis of findings from healthy and neuropsychiatric populations [J]. Brain Stimul, 2016, 9(2): 197-208.
[24] Zaehle T, Sandmann P, Thorne JD, et al. Transcranial direct current stimulation of the prefrontal cortex modulates working memory performance: combined behavioural and electrophysiological evidence [J]. BMC Neurosci, 2011, 12(1):1-11.
[25] Carvalho S, Boggio PS, Scar F, et al. Transcranial direct current stimulation based metaplasticity protocols in working memory [J]. Brain Stimul, 2015, 8(2): 289-294.
[26] Boggio PS, Ferrucci R, Rigonatti SP, et al. Effects of transcranial direct current stimulation on working memory in patients with Parkinson's disease [J]. J Neurol Sci, 2006, 249(1):31-38.
[27] Jo JM, Kim YH, Ko MH, et al. Enhancing the working memory of stroke patients using tDCS [J]. Am J Phys Med Rehabil, 2009, 88(5):404-409.
[28] Boggio PS, Khoury LP, Martins DC, et al. Temporal cortex direct current stimulation enhances performance on a visual recognition memory task in Alzheimer disease [J]. Journal of Neurology Neurosurgery & Psychiatry, 2009, 80(4):444-447.
[29] Nitsche MA, Schauenburg A, Lang N, et al. Facilitation of implicit motor learning by weak transcranial direct current stimulation of the primary motor cortex in the human [J]. Journal of Cognitive Neuroscience, 2003, 15(4):619-626.
[30] Ammann C, Spampinato D, Márquez-Ruiz J. Modulating motor learning through transcranial direct-current stimulation: An integrative view [J]. Frontiers in Psychology, 2016, 7:1981.
[31] Ehsani F, Bakhtiary AH, Jaberzadeh S, et al. Differential effects of primary motor cortex and cerebellar transcranial direct current stimulation on motor learning in healthy individuals: A randomized double-blind sham-controlled study [J]. Neuroscience Research, 2016, 112:10-19.
[32] Panico F, Sagliano L, Grossi D, et al. Cerebellar cathodal tDCS interferes with recalibration and spatial realignment during prism adaptation procedure in healthy subjects [J]. Brain & Cognition, 2016, 105:1-8.
[33] Galea JM, Celnik P. Brain polarization enhances the formation and retention of motor memories [J]. Journal of Neurophysiology, 2009, 102(1):294-301.
[34] Cabral ME, Baltar A, Borba R, et al. Transcranial direct current stimulation: before, during, or after motor training?[J]. Neuroreport, 2015, 26:618-622.
[35] Kang N, Summers JJ, Cauraugh JH. Transcranial direct current stimulation facilitates motor learning post-stroke: A systematic review and meta-analysis [J]. Journal of Neurology Neurosurgery & Psychiatry, 2016, 87(4):345-355.
[36] Petersen SE, Posner MI, Manuscript A. The attention system of the human brain: 20 years after [J]. Annual Review of Neuroscience, 2012, 35(35):73-89.
[37] Roy LB, Sparing R, Fink GR, et al. Modulation of attention functions by anodal tDCS on right PPC [J]. Neuropsychologia, 2015, 74:96-107.
[38] Falcone B, Coffman BA, Clark VP, et al. Transcranial direct current stimulation augments perceptual sensitivity and 24-hour retention in a complex threat detection task [J]. PLoS ONE, 2012, 7(4):e34993.
[39] Coffman BA, Trumbo MC, Clark VP. Enhancement of object detection with transcranial direct current stimulation is associated with increased attention [J]. BMC Neuroscience, 2012, 13(1):1-8.
[40] Shin YI, Foerster A, Nitsche MA. Transcranial direct current stimulation (tDCS) - Application in neuropsychology [J]. Neuropsychologia, 2015, 69(2):154-175.
[41] Stone DB, Tesche CD. Transcranial direct current stimulation modulates shifts in global/local attention [J]. Neuroreport, 2009, 20(12):1115-1119.
[42] Gladwin TE, den Uyl TE, Fregni FF, et al. Enhancement of selective attention by tDCS: interaction with interference in a Sternberg task [J]. Neuroscience Letters, 2012, 512(1):33-37.
[43] Pecchinenda A, Ferlazzo F, Lavidor M. Modulation of selective attention by polarity-specific tDCS effects [J]. Neuropsychologia, 2015, 68:1-7.
[44] Schacter DL. Adaptive constructive processes and the future of memory [J]. American Psychologist, 2012, 67(8):603-613.
[45] Antal A, Nitsche MA, Paulus W. External modulation of visual perception in humans [J]. Neuroreport, 2001, 12(16):3553-3555.
[46] Antal A, Kincses TZ, Nitsche MA, et al. Modulation of moving phosphene thresholds by transcranial direct current stimulation of V1 in human [J]. Neuropsychologia, 2003, 41(13):1802-1807.
[47] Antal A, Kincses TZ, Nitsche MA, et al. Manipulation of phosphene thresholds by transcranial direct current stimulation in man [J]. Experimental Brain Research.experimentelle Hirnforschung.expérimentation Cérébrale, 2003, 150(3):375-378.
[48] Antal A, Kincses TZ, Nitsche M A, et al. Excitability changes induced in the human primary visual cortex by transcranial direct current stimulation: direct electrophysiological evidence [J]. Investigative Ophthalmology & Visual Science, 2004, 45(2):702-707.
[49] Barbieri M, Negrini M, Nitsche MA, et al. Anodal-tDCS over the human right occipital cortex enhances the perception and memory of both faces and objects [J]. Neuropsychologia, 2015, 81:238-244.
[50] Zaehle T, Beretta M, Jncke L, et al. Excitability changes induced in the human auditory cortex by transcranial direct current stimulation: direct electrophysiological evidence [J]. Experimental Brain Research, 2011, 215(2):135-140.
[51] Impey D, Knott V. Effect of transcranial direct current stimulation (tDCS) on MMN-indexed auditory discrimination: a pilot study [J]. Journal of Neural Transmission, 2015, 122(8):1175-1185.
[52] Fregni F, Marcondes R, Boggio PS, et al. Transient tinnitus suppression induced by repetitive transcranial magnetic stimulation and transcranial direct current stimulation [J]. European Journal of Neurology, 2006, 13(9):996-1001.
[53] Vanneste S, Walsh V, Heyning P V D, et al. Comparing immediate transient tinnitus suppression using tACS and tDCS: A placebo-controlled study [J]. Experimental Brain Research, 2013, 226(1):25-31.
[54] Costa TL, Lapenta OM, Boggio PS, et al. Transcranial direct current stimulation as a tool in the study of sensory-perceptual processing [J]. Attention Perception & Psychophysics, 2015, 77(6):1813-1840.
[55] Rogalewski A, Breitenstein C, Nitsche MA, et al. Transcranial direct current stimulation disrupts tactile perception [J]. European Journal of Neuroscience, 2004, 20(1):313-316.
[56] Matsunaga K, Nitsche MA, Tsuji S, et al. Effect of transcranial DC sensorimotor cortex stimulation on somatosensory evoked potentials in humans [J]. Clinical Neurophysiology, 2004, 115(2):456-460.
[57] Bachmann CG, Muschinsky S, Nitsche MA, et al. Transcranial direct current stimulation of the motor cortex induces distinct changes in thermal and mechanical sensory percepts [J]. Clinical Neurophysiology, 2010, 121(12):2083-2089.
[58] Boggio PS, Rocha RR, Da SM, et al. Differential modulatory effects of transcranial direct current stimulation on a facial expression go-no-go task in males and females [J]. Neuroscience Letters, 2008, 447(2-3):101-105.
[59] Peagómez C, Vidalpieiro D, Clemente IC, et al. Down-regulation of negative emotional processing by transcranial direct current stimulation: effects of personality characteristics [J]. PLoS ONE, 2011, 6(7):e22812.
[60] Nitsche MA, Koschack J, Pohlers H, et al. Effects of frontal transcranial direct current stimulation on emotional state and processing in healthy humans [J]. Frontiers in Psychiatry, 2012, 3(58):58.
[61] Ferrucci R, Giannicola G, Rosa M, et al. Cerebellum and processing of negative facial emotions: cerebellar transcranial DC stimulation specifically enhances the emotional recognition of facial anger and sadness [J]. Cogn Emot, 2012, 26(5):786-799.
[62] Willis ML, Murphy JM, Ridley NJ, et al. Anodal tDCS targeting the right orbitofrontal cortex enhances facial expression recognition [J]. Social Cognitive & Affective Neuroscience, 2015, 10(12):1677-1683.
[63] Loo CK, Alonzo A, Martin D, et al. Transcranial direct current stimulation for depression: 3-week, randomised, sham-controlled trial [J]. British Journal of Psychiatry the Journal of Mental Science, 2012, 200(1):52-59.
[64] Palm U, Hasan A, Strube W, et al. tDCS for the treatment of depression: a comprehensive review [J]. Eur Arch Psychiatry Clin Neurosci, 2016, 266(8):681-694.
[65] Fecteau S, Knoch D, Fregni F, et al. Diminishing risk-taking behavior by modulating activity in the prefrontal cortex: A direct current stimulation study [J]. Journal of Neuroscience, 2007, 27(46):12500-12505.
[66] Chrysikou EG, Gorey C, Aupperle RL. Anodal transcranial direct current stimulation over right dorsolateral prefrontal cortex alters decision making during approach-avoidance conflict [J]. Social Cognitive & Affective Neuroscience, 2016, 12(3):468-475.
[67] Mengarelli F, Spoglianti S, Avenanti A, et al. Cathodal tDCS over the left prefrontal cortex diminishes choice-induced preference change [J]. Cerebral Cortex, 2015, 25(5):1219-1227.
[68] Ouellet J, Mcgirr A, Van d EF, et al. Enhancing decision-making and cognitive impulse control with transcranial direct current stimulation (tDCS) applied over the orbitofrontal cortex (OFC): A randomized and sham-controlled exploratory study [J]. Journal of Psychiatric Research, 2015, 69:27-34.
[69] Pripfl J, Neumann R, Khler U, et al. Effects of transcranial direct current stimulation on risky decision making are mediated by ‘hot’ and ‘cold’ decisions, personality, and hemisphere [J]. European Journal of Neuroscience, 2013, 38(12):3778-3785.
[70] Flel A. tDCS-enhanced motor and cognitive function in neurological diseases [J]. Neuroimage, 2014, 85(2):934-947.
[71] Horvath JC, Carter O, Forte JD. Transcranial direct current stimulation: five important issues we aren't discussing (but probably should be) [J]. Frontiers in Systems Neuroscience, 2014, 8:2.
[72] Giordano J, Bikson M, Kappenman ES, et al. Mechanisms and effects of transcranial direct current stimulation [J]. Dose Response, 2017, 15(1):1559325816685467.
[73] To WT, Hart J, Ridder DD, et al. Considering the influence of stimulation parameters on the effect of conventional and high-definition transcranial direct current stimulation [J]. Expert Rev Med Devices, 2016, 13(4):391-404.