Research on Effects of Transcranial Direct Current Stimulation on EEG in Children with Autism Spectrum Disorder
Wen Fang1, Pang Jiao2, Li Xiaoli3, Kang Jiannan2*
1(Department of Psychiatry, Beijing Children′s Hospital, Capital Medical University, National Center for Children′s Health, Beijing 100045, China) 2(Institute of Information Engineering, Hebei University, Baoding 071000, China) 3 (State Key Laboratory of Cognitive Neuroscience and Learning, Beijing Normal University, Beijing 100875, China)
Abstract：The autism spectrum disorder (ASD) is a complex developmental disorder characterized by impairments of social communication and repetitive behaviors. Transcranial direct current stimulation (tDCS) is a non-invasive brain stimulation technique that can be conducted on many neuropsychiatric and neurological disorders such as epilepsy, Parkinson’s disease, Alzheimer’s disease, major depression and schizophrenia. It is safe and easy-to-use, because thousands of tDCS sessions have been reported without any serious adverse effects. In this study, we enrolled 24 ASD children who received transcranial direct current stimulation (tDCS) brain modulation. Among those, 12 ASD children received 10 treatments over the dorsolateral prefrontal cortex (DLPFC) twice a week and the other 12 ASD children received sham-stimulation twice a week as controls. Power spectrum and multiscale entropy algorithm were used to evaluate the effects. Results showed that 4~8 Hz theta band decreased significantly (P<0.05) in the whole brain before and after intervention, the frontal lobe decreased from (1.13±0.07) dB/Hz to (0.96±0.06)dB/Hz, from (1.18±0.05) dB/Hz to (1.03±0.07)dB/Hz in the left temporal lobe, from (1.43±0.06) dB/Hz to (1.16±0.03)dB/Hz in the central region, from (1.14±0.09) dB/Hz to (0.96±0.04)dB/Hz in the right temporal lobe, and from (1.39±0.06) dB/Hz to (1.09±0.03)dB/Hz in the occipital lobe. Entropy values in parietal lobe (P3, Pz, C3, C4), occipital lobe (O1) and DLPFC (F3) were significantly increased by calculating the entropy values at 15 scales after intervention. The tDCS had positive effects on the autistic children and it was safe and non-invasive, therefore it would be helpful for the rehabilitation of autistic children.
闻芳, 庞姣, 李小俚, 康健楠. 经颅直流电刺激对孤独症谱系障碍儿童脑电的影响研究[J]. 中国生物医学工程学报, 2019, 38(5): 566-572.
Wen Fang, Pang Jiao, Li Xiaoli, Kang Jiannan. Research on Effects of Transcranial Direct Current Stimulation on EEG in Children with Autism Spectrum Disorder. Chinese Journal of Biomedical Engineering, 2019, 38(5): 566-572.
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