Research on the Relationship Between Mechanical Properties of 3D Printed Hydroxyapatite Scaffolds and Inner Structures
Li Xiangcheng1, Suo Hairui2,3, Wang Ling2,3, Xu Mingen2,3*
1(School of Life Information and Instrument Engineering, Hangzhou Dianzi University, Hangzhou 310018, China) 2(School of Automation, Hangzhou Dianzi University, Hangzhou 310018, China) 3(Zhenjiang Provincial Key Lab of Medical Information and Three-Dimensional Bio-Printing, Hangzhou 310018, China)
Abstract：3D printed bone tissue engineering scaffolds are becoming hotspot recently, and preparation of bone tissue engineering scaffolds with high porosity and sufficient mechanical properties is still one of the difficulties in current research. The purpose of this study was to investigate the effects of different filling angle structures on the mechanical properties of 3D printing scaffold with the same porosity. Firstly, three different filling angle (45°, 60°, 90°) scaffold structures with the same porosity were designed by SolidWorks software, the structure of the intersection point was used as the minimum support unit of the scaffold, and it′s mechanical properties were simulated by ABAQUS software. Next, the compression modulus of the structure unit was accumulated to investigate the effect of filling angle on the mechanical properties of the scaffold. Three kinds of hydroxyapatite scaffolds with inner structure were prepared by 3D printing, and the porosity and mechanical properties of the scaffolds were tested to verify the simulation results. Results showed that the compression modulus ratio of the three inner structures obtained by simulation was Es(90°)∶Es(60°)∶Es (45°)=12.3:10.9:10.0. There were no significant differences in the porosity of the hydroxyapatite scaffolds among the three different filling angles (90°, 60°, 45°), and the compression modulus ratio was Es(90°):Es(60°):Es(45°)=15.4:13.1:10.0, consistent with the simulation results. The 90° scaffold had the highest compressive strength (7.36 ± 0.63) MPa and compressive modulus (33.55 ± 2.49) MPa. Compared with the 45° scaffold, the compressive strength of 90° scaffold was increased by 74.8% and the compressive modulus was increased by 55.18%. With the same porosity, the scaffold with smaller area of single pore showed higher compressive modulus and compressive strength. This study provided an analytical method and theoretical basis for the preparation of 3D printed biological scaffolds with optimal inner structure.
李相成, 索海瑞, 王玲, 徐铭恩. 基于3D打印羟基磷灰石支架的填充结构与力学性能研究[J]. 中国生物医学工程学报, 2020, 39(1): 91-96.
Li Xiangcheng, Suo Hairui, Wang Ling, Xu Mingen. Research on the Relationship Between Mechanical Properties of 3D Printed Hydroxyapatite Scaffolds and Inner Structures. Chinese Journal of Biomedical Engineering, 2020, 39(1): 91-96.
