Abstract:The aim of this work is to investigate the optimized analysis on the femur finite element model in the distribution gradient of material attributes, getting the precise and economic divided layers, which can be used as the theoretical support for the application of CT gray value assignment in the research area of medical finite element. The femur of an adult volunteer was firstly selected for CT scanning, the obtained DICOM format CT serial medicinal image data were input into Mimics, and the 3D rendering model was constructed. On this basis, using SolidWorks to substantiate the model, importing it into HyperMesh for volume mesh division, and then returning to Mimics, choosing layer 2, 4, 5, 10, 50, 100, 200 and 400 eight kinds of the gradient for material assignment. Finally, the working condition of the finite element model was set in ABAQUS software for simulation analysis. At the same time, the femur proxima finite element was established, and its validity was verified through the comparative analysis with literature data. Results showed that the level of stress and strain of the established femur finite element model had similar results with the experimental results in the literature; thus the effectiveness of the femoral finite element model was fully verified. The optimized analysis on the distribution gradient of material attributes: compared with the material properties of other layers, the stress of layer 2, 4, 5 and 400 was significantly different (P<0.05), and the stress between the four groups of material properties was significantly different (P<0.05),while the stress results of layer 10, 50, 100 and 200 were not significantly different. The material properties of the finite element model should be divided in an appropriate way. We found out that the material properties in 10 layers could not only improve the calculation speed and save the calculation amount, but also ensure the accuracy of the calculation results; the CT gray value assignment could be used to the analysis on the clinical individualized rapid finite element simulation.
金乾坤, 王巍, 何盛为, 何飞熊, 陈秉智, 傅彦棉. 股骨有限元模型材料属性分配梯度的优化分析[J]. 中国生物医学工程学报, 2020, 39(1): 84-90.
Jin Qiankun, Wang Wei, He Shengwei, He Feixiong, Chen Bingzhi, Fu Yanmian. The Optimized Analysis on the Distribution Gradient of Material Attributes of Femur Finite Element Model. Chinese Journal of Biomedical Engineering, 2020, 39(1): 84-90.
[1] Michiaki M, Junichi N, Yusuke M, et al. Prediction of fracture load and stiffness of the proximal femur by CT-based specimen specific finite element analysis: cadaveric validation study [J]. BMC MusculoskeletalDisorders, 2017, 18(1): 536-544.
[2] Rajapakse CS, Chang G. Micro-finite element analysis of the proximal femur on the basis of high-resolution magnetic resonance images [J]. Current Osteoporosis Reports, 2018, 16(1): 657-664.
[3] 金乾坤,何盛为,何飞熊,等. 足踝部三维有限元仿真模型的构建及验证 [J]. 中国数字医学, 2016, 11(4): 83-86.
[4] 潘连强,吴广辉,刘玉倩,等. 冠脉重叠支架虚拟置入的有限元分析 [J]. 中国生物医学工程学报, 2018, 37(5):576-583.
[5] Sofuoglu H, Cetin ME. An investigation on mechanical failure of hip joint using finite element method [J]. Eng-Biomed Tech, 2015, 60(6): 603-616.
[6] Zach L, Kunčická L,R ůžička P, et al. Design, analysis and verification of a knee joint oncological prosthesis finite element model [J]. Computers in Biology and Medicine, 2014, 54(8): 53-60.
[7] Martelli S, Kersh ME, Schache AG, et al. Strain energy in the femoral neck during exercise [J]. Journal of Biomechanics, 2014, 47(8): 1784-1791.
[8] Hellwig FL, Tong J, Hussell JG. Hip joint degeneration due to cam impingement: A finite element analysis [J]. Computer Methods in Biomechanics and Biomedical Engineering, 2016, 19(1): 41-48.
[9] 王浩军,杨燕,屈瑞娜. 基于Matlab的批量转换DICOM格式CT序列图像的实现 [J]. 科技资讯, 2017, 15(12): 8-11.
[10] Wirtz DC, Schiffers N, Pandorf T, et al. Critical evaluation of known bone material properties to realize anisotropic FE-simulation of the proximal femur [J]. J Biomech, 2000, 33(10): 1325-1330.
[11] Marom SA, Linden MJ. Computer aided stress analysis of long bones utilizing computed tomography [J]. J Bion Mech, 1990, 23(5): 399-404.
[12] 裴葆青,师振鹏,王唯,等. 后路固定术治疗胸腰椎爆裂骨折的生物力学研究 [J]. 中国生物医学工程学报, 2017, 36(6): 718-723.
[13] Zannoni C, Mantovani R, Viceconti M. Material properties assignment to finite element models of bone structures: A new method [J]. Med Eng Phys, 1999, 20(10): 735-740.
[14] Kluess D, Souffrant R, Mittelmeier W, et al. A convenient approach for finite-element-analyses of orthopaedic implants in bone contact: Modeling and experimental validation [J]. Comput Methods Programs Biomed, 2009, 95(1): 23-30.
[15] Taddei F, Pancanti A, Viceconti M. An improved method for the automatic mapping of computed tomography numbers onto finite element models [J]. Med Eng Phys, 2004, 26(1): 61-69.
[16] 储小兵,杨予,郝改平,等. 新研制的老年不稳定型股骨粗隆间骨折半髋假体有限元分析 [J]. 中国生物医学工程学报, 2012, 31(5): 729-735.
[17] Ciarelli MJ, Goldstein SA, Kuhn JL, et al. Evaluation of orthogonal mechanical properties and density of human trabecular bone from the major metaphyseal regions with materials testing and computed tomography [J]. J Orthop Res, 1991, 9(5): 674-682.
[18] Rho JY, Hobatho MC, Ashman RB. Relations of mechanical properties to density and CT numbers in human bone [J]. Med Eng Phys, 1995, 17(5): 347-355.
[19] Lengsfeld M, Schmitt J, Alter P, et al. Comparison of geometry-based and CT voxel-based finite element modelling and experimental validation [J]. Med Eng Phys, 1998, 20(7): 515-522.
[20] 张国栋,廖维靖,陶圣祥,等. 股骨颈有限元分析的赋材料属性方法探讨及有效性验证 [J]. 中国组织工程研究与临床康复, 2009, 13(52): 10263-10268.
[21] Simes JA, Vaz MA, Blatcher S, et al. Influence of head constraint and muscle forces on the strain distribution within the intact femur [J]. Medical Engineering and Physics, 2000, 22(7):453-459.
[22] 马剑雄,马信龙,张清功,等. 三维有限元模型评价股骨正常站立位的生物力学特性 [J]. 中国组织工程研究与临床康复, 2008, 12(35): 6823-6826.
[23] 张弢,张清功,马信龙,等. 应用CT断层图像重建股骨有限元模型 [J]. 生物医学工程与临床, 2008, 12(6): 446-450.
[24] 钟务学,朱建民,张银网,等. 体绘制分体建模法建立人体股骨有限元模型 [J]. 中国骨与关节外科, 2012, 5(1): 48-53.
[25] Yi W, Tian Q, Dai Z, et al. Mechanical behaviour of umbrella-shaped, Ni-Ti memory alloy femoral head support device during implant operation: A finite element analysis study [J]. PLoS ONE, 2014, 9(6): e100765.
[26] 樊黎霞, Wang E. 人在摔倒时股骨上端承载能力的有限元分析(I):有限元分析模型及股骨失效准则的建立 [J]. 生物医学工程学杂志, 2006, 23(5): 1028-1032.
[27] Lu Fu, Zhao Hongwei, Zhu Yuxiang, et al. Biomechanics analysis of human proximal femur under four different standing postures based on finite element method [C]//IEEE Symposium on Robotics and Applications(ISRA). Kuala Lumpur: IEEE, 2012:122-124.
[28] San Antonio T, Ciaccia M, Müller-Karger C, et al. Orientation of orthotropic material properties in a femur FE model: A method based on the principal stresses directions [J]. Medical Engineering and Physics, 2012, 34(7):914-919.
[29] Zohar Y, Nir T, Milgrom C. Reliable simulations of the human proximal femur by high-order finite element analysis validated by experimental observations [J]. J Biomech, 2007, 40(16): 3688-3699.
[30] 董鹏飞,雷建银,刘海波,等. 基于CT图像的股骨上段有限元建模及单元尺寸分析 [J]. 医用生物力学, 2016, 31(2): 129-134.
[31] 张美超,钟世镇. 国内生物力学中有限元的应用研究进展 [J]. 解剖科学进展, 2003, 9(1): 53-56.
[32] 苟福兴,刘雄,张美超. 材料属性分配梯度对椎体有限元模型力学性能的影响 [J]. 医用生物力学, 2013, 28(4): 432-435.
[33] 张国栋,廖维靖,陶圣祥,等. 股骨有限元分析赋材料属性的方法 [J]. 中国组织工程研究与临床康复, 2009, 13(43): 8436-8441.