The Research Progress of Transcranial Direct Current Stimulation in the Treatment of Alzheimer′s Disease
Luo Yinpei1, Li Nian1, Wen Huizhong2*, Tian Xuelong1*
1(School of Bioengineering, Chongqing University, Chongqing 400044, China) 2(Department of Neurobiology, College of Basic Medical Sciences, Army Medical University, Chongqing Key Laboratory of Neurobiology, Chongqing 400038, China)
Abstract：Alzheimer′s disease (AD) is an irreversible neurodegenerative disease that seriously affects the physical and mental health and daily activities of patients. It is currently not possible to effectively prevent the course of AD through drug and cognitive training. Transcranial direct current stimulation (tDCS) is a non-invasive neuromodulation technique that is safe, economical, and well tolerated. It has been widely used in many studies of neurodegenerative diseases in recent years. Studies have found out that tDCS can improve learning and memory and cognitive dysfunction in AD patients by regulating synaptic accessibility, participating in inflammation regulation and regulating local blood flow. Therefore, tDCS is a very promising treatment for AD. In order to better understand and promote the application of tDCS in AD, this paper reviewed the application status and mechanisms of tDCS in AD.
罗尹培, 李念, 温惠中, 田学隆. 经颅直流电刺激技术在阿尔茨海默症治疗中的研究进展[J]. 中国生物医学工程学报, 2019, 38(5): 609-620.
Luo Yinpei, Li Nian, Wen Huizhong, Tian Xuelong. The Research Progress of Transcranial Direct Current Stimulation in the Treatment of Alzheimer′s Disease. Chinese Journal of Biomedical Engineering, 2019, 38(5): 609-620.
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