The Effect of Cryopreservation on Biospecimens and Biomacromolecules
Liang Wei1,2, Wang Meixia1, Liu Baolin1*
1Institute of Biothermal Science and Technology, University of Shanghai for Science and Technology, Shanghai 200093, China 2Xin Hua Hospital Affiliated to Shanghai Jiaotong University School of Medicine, MOE-Shanghai Key Laboratory of Children’s Environmental Health, Shanghai 200092, China
Abstract：The role of biobanking in modern medical research is becoming more and more important with the endless achievements based on biobanks, which greatly promotes the development of translational medicine. The qualities of the specimens from biobanks have a great effect on the reliability of the researches. So how to guarantee the qualities of the samples is the key of the research on biobanks. Cryopreservation technology can maintain the viability of the specimens, which will play a significant role in the development of biobanks if preserving the complete molecular information and maintaining the viabilities of the specimens. The damage which freezing or cold brings to the specimens (especially to the biological macromolecules of the samples) and how to reduce these damages are reviewed in this article.
梁玮, 王美霞, 刘宝林. 低温保存对生物样本及其生物大分子的影响[J]. 中国生物医学工程学报, 2017, 36(5): 615-621.
Liang Wei, Wang Meixia, Liu Baolin. The Effect of Cryopreservation on Biospecimens and Biomacromolecules. Chinese Journal of Biomedical Engineering, 2017, 36(5): 615-621.
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