Abstract：The three-dimensional scaffold cell culture technology has achieved a good spatial structure in the process of cell cultivation; however there are still lack of channel structures such as vascular network in the 3D scaffolds. Therefore current 3D scaffolds can not entirely simulate the growing environment of internal cells of the human body. Referring to the method of constrained structure optimization, this article built a simulated three-dimensional vascular network that was constructed inside the STL model of biological scaffold by computer software on the basis of common three-dimensional biological scaffold and created a new kind of three-dimensional biological scaffold model and printed the material objects using 3D biological printer. Through the statistical analysis of scaffold model and compared with the digital model, the differences between the printed scaffold model and the digital model were within 5%, which met the design requirements. By this technique the liquid circulation inside the cell culture scaffold was increased and the structure of scaffold was closer to the internal environment of the human body. The research can also make it possible to simulate and figure out factors of affecting the liquid circulation inside the human body has on the growth of cells.
刘 翀, 徐铭恩, 王 玲, 宋江新. 基于3D打印细胞培养支架内部血管通道的模拟与构建[J]. 中国生物医学工程学报, 2017, 36(1): 67-74.
Liu Chong, Xu Mingen, Wang Ling, Song Jiangxin. Simulation and Fabrication of Vascular Network in Biological Scaffolds Based on Three-Dimensional Cell Printing Technique. Chinese Journal of Biomedical Engineering, 2017, 36(1): 67-74.
