Study on the Particle Motion Behavior and Separation Efficiency in Microchannels of the Magnetophoretic Separation System
1 Wuhan Medical Care Center for Women and Children Affiliated to Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430016,China
2 Wuhan National High Magnetic Field Center, Huazhong University of Science and Technology, Wuhan 430074, China
Abstract：Magnetophoretic separation technology by use of magnetic forces on the micro/nano particles for transporting and separating has attracted wide attention in the fields of biochemical separation and detection. Its applications in microfluidics with corresponding studies of separation behavior in microscale have been one hot issue in the research field. Based on the equations of forces acting on the particles and motion behavior, this paper established a two dimensional dynamical numerical model for particles under the action of gradient magnetic field and flow field. Then the motion behavior and separation efficiency of particles with single/double sizes were investigated for different flow rates and microchannel structures. Studies have shown that: 1) Widths of the two fluid streams flowing in the Tshaped microchannel can be controlled by adjusting the flow rate ratio of the two inlets. The width of the stream containing particles can be decreased from 100 μm to 53 μm when the inlet flow rate ratio changes from 1 to 6, which has greatly decreased the initial distances between partilces and could be used to improve the separation resolution. 2) When the two types of magnetic particles have been separated completely, the spacing distance between fully separated particles can be greatly amplified from 5.4 μm to 26.8 μm by introducing a broadened segment along the channel outlet. Then it has been demonstrated to realize the separation of 2 μm and 3 μm particles. These results should have a theoretical significance to enhance the magnetophoretic separation efficiency and optimize the microfluidic system.
韦卫中1 曹全梁2 冯洋2 韩小涛2*. 微通道磁泳分离系统中微粒的运动特性及分离效率研究[J]. 中国生物医学工程学报, 2015, 34(1): 17-23.
Wei Weizhong1 Cao Quanliang2 Feng Yang2 Han Xiaotao2*. Study on the Particle Motion Behavior and Separation Efficiency in Microchannels of the Magnetophoretic Separation System. journal1, 2015, 34(1): 17-23.
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