Abstract：Malignant tumors have a high fatality rate and pose a serious threat to human health. Conventional surgical treatment, chemotherapy, and radiotherapy have certain drawbacks. As an emerging treatment method, tumor electrostimulation (ES) therapy has been clinically verified for its excellent safety and therapeutic effect, but energy supply insufficiency and equipment technology issues have hindered its further clinical application. With the rapid development of materials science, nanoscience, and micro-nano processing technology, self-powered technology has emerged, providing a new solution for tumor ES therapy. This review first introduced the working principle of self-powered technology, then discussed the research progress of self-powered tumor ES therapy, including self-powered electroporation (EP) therapy, self-powered electrochemical therapy (ECT), self-powered triboelectric immunotherapy (TIT), and self-powered dynamic therapy (DT). Finally,the latest work of self-powered technology in tumor detection and prevention of tumor metastasis was presented, along with core challenges in tumor therapy related to the mechanisms of electrical stimulation, treatment methods, devices and clinical application. The review also discussed the future development directions,to provide new ideas and strategies for tumor treatment.
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