Advances in Electrophysiological Research of Spinal Cord Stimulation on Freezing of Gaitin Parkinson′s Disease
Li Ziyun1, Li Jiping2, Wei Jing1*
1(School of Biomedical Engineering, Capital Medical University, Beijing 100069, China) 2(Department of Functional Neurosurgery, Xuanwu Hospital, Capital Medical University, Beijing 100053, China)
Abstract：Freezing of gait (FoG) is a severe symptom of Parkinson's disease (PD), which has a high incidence rate and seriously affects the quality of life of patients. Currently, there are no ideal methods for the treatment of FoG. Spinal cord stimulation (SCS) is a therapeutic way of electrical stimulation of the spinal cord, which has the advantage of causing less surgical trauma. From the perspective of SCS technology to improve the electrophysiological treatment mechanism of FoG, this paper first introduced the abnormal anatomical mechanism of FoG, followed by reviewing the research progress of abnormal electrophysiology of FoG from the level of cortex and deep brain, and then discussed the electrophysiological mechanism of SCS regulation of FoG from the clinical and animal models. Finally, we summarized the limitations and deficiencies of the current SCS and explored application prospects, possible improvement directions, and future development trends of SCS in the treatment of FoG.
李梓赟, 李继平, 魏婧. 脊髓电刺激治疗帕金森病步态冻结症状的电生理学研究进展[J]. 中国生物医学工程学报, 2023, 42(5): 603-609.
Li Ziyun, Li Jiping, Wei Jing. Advances in Electrophysiological Research of Spinal Cord Stimulation on Freezing of Gaitin Parkinson′s Disease. Chinese Journal of Biomedical Engineering, 2023, 42(5): 603-609.
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