磁响应性三元复合材料制备及引导骨缺损修复的研究

doi:10.3969/j.issn.0258-8021.2015.03.010

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Abstract Bone tissue cannot accomplish selfhealing in critical size bone defects resulted from trauma, infection, tumor and congenital malformation. Using biomaterials that induce bone tissue regeneration to repair bone defects is an extremely important therapeutic strategy. However, slow bone formation is one of the difficulties in biomaterialinduced bone regeneration. In this work, a magnetic responsive nanofibrous composite film was fabricated with poly lactide acid (PLA), hydroxyapatite nanoparticles (nHA) and γFe2O3 nanoparticles (γFe2O3 NP) using electrospinning technique. The film was folded into a 3D scaffold that suitable for implantation in bone defect sites. The relationship between magnetic properties of composite materials and the percentage of iron oxide magnetic nanoparticles was investigated using vibrating sample magnetometer (VSM). The microstructure of films was observed by scanning electron microscopy (SEM). The effect of magnetic responsive composites on inducing bone repair and regeneration in situ under an applied magnetic field was evaluated in bone transverse process disartitulation model of 12 healthy male New Zealand rabbits after 10,30,50 days implantation. Results indicate that the composite display a strong paramagnetic property and show a positive correlation with the proportion of iron oxide nanoparticles. In an applied magnetic field, the bone tissue regeneration in the disarticulation sites was accelerated with the guidance of the composite scaffold.

Key words： bone repair iron oxide magnetic particles composite nanofibrous scaffold

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http://cjbme.csbme.org/EN/10.3969/j.issn.0258-8021.2015.03.010 OR http://cjbme.csbme.org/EN/Y2015/V34/I3/330

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