基于有限元-神经元模型的大鼠硬膜外脊髓电刺激仿真研究

doi:10.3969/j.issn.0258-8021. 2015. 03.007

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Abstract Clinical research demonstrated that epidural spinal cord stimulation (ESCS) was able to facilitate motor function recovery after spinal cord injury, but the underlying neural mechanism must be explored by animal experiments. In this paper, based on the construction of finite element and neuron model of ESCS, the distribution of electric potentials was simulated in the rat spinal cord with a stimulating cathode located at the midpoint of L2 spinal segment. The excitation thresholds of typical spinal fibers were calculated to analyze the influence of the fiber location and pulse width on the recruitment of nerve fibers. The simulation results showed that the dorsal root fiber entering the spinal cord at the cathode level had the lowest excitation threshold of 041 V, whereas the excitation threshold of the ventral root fiber at the same level was 078 V and much higher than that of the most superficial dorsal column fiber with the excitation threshold of 047 V. The decrease of the fiberelectrode distance was able to improve the selectivity of fiber activation. It was also shown that the excitation threshold of dorsal column fibers at different depths within the midsagittal plane of spinal cord decreased with the increase of pulse width, whereas too long pulse width corresponded to the decreased slope of the varied activation threshold for dorsal column fibers. Therefore, the choice of an appropriate pulse width is essential to the activation of deep dorsal column fibers and the increasing activated area of the stimulated tissue. Our simulation results would offer guidance for the selection of stimulation parameters and the improvement of the stimulation selectivity during animal experiments.

Key words： finite element model neuron model epidural spinal cord stimulation rat spinal cord fiber

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http://cjbme.csbme.org/EN/10.3969/j.issn.0258-8021. 2015. 03.007 OR http://cjbme.csbme.org/EN/Y2015/V34/I3/308

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