蜂窝状聚氨酯支架的制备及性能评价

doi:10.3969/j.issn.0258-8021. 2014. 05.010

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Abstract In this study, poly (εcaprolactone) diol was synthesized via ringopening polymerization of εcaprolactone using 2,2′dithiodiethanol as an initiator, and then polyurethane was synthesized through addition polymerization of poly (εcaprolactone) and hexamethylene diisocyanate. Polyurethane was characterized by FTIR, XRD and DSC. Polyurethane scaffolds were fabricated by biotemplating technique, and their porous structure, porosity and mechanical properties were characterized by SEM, archimedes principle based method and mechanical test, respectively. MC3T3E1 cells were cultured on polyurethane scaffolds to evaluate their cytocompatibility. The results indicated that polyurethane scaffolds had a honeycomblike channels with a diameter range of 100 μm to 140 μm, and their porosity and compressive modulus were 772%±41% and 29902 kPa, respectively. Immunofluorescence staining and live/dead staining results indicated that MC3T3E1 cells could adhere and proliferate on the scaffolds. The results suggested that the honeycomblike polyurethane scaffolds were a promising candidate for bone tissue engineering.

Key words： polyurethane porous scaffolds honeycomblike bone tissue engineering

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	XU Wei Jun QIAN Jun Min^* JIN Xin Xia

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XU Wei Jun QIAN Jun Min^* JIN Xin Xia. Fabrication and Evaluation of Polyurethane Scaffolds with HoneycombLike Structure[J]. journal1, 2014, 33(5): 593-599.

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http://cjbme.csbme.org/EN/10.3969/j.issn.0258-8021. 2014. 05.010 OR http://cjbme.csbme.org/EN/Y2014/V33/I5/593

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