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Research Progress on AdiposeDerived Stem Cells in Cartilage Tissue Engineering |
School of Stomatology, Jilin University, Changchun 130021, China |
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Abstract The potential for adiposederived stem cells (ADSCs) of differentiating into chondrocytes has attracted increasing attentions in recent years. As seed cells, ADSCs have broad prospects in the use of cartilage tissue engineering. However, methods to obtain high quality cells are still lack and have
not been recognized in the world. Although various methods such as exogenous growth factors, genetic modification, coculture, growth factors ally with coculture, and scaffold materials can induce the differentiation of ADSCs into chondrocytes, the pros and cons of each method, signaling pathways of differentiation and traits of neochondrocytes are not clear in detail. This paper introduced the status and problems of multiple methods mentioned above, and discussed the influence of the chemical factors, donor age, organizations to get parts etc. on the cell culture, aiming to provide a theoretical reference for the clinical application of ADSCs.
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