脂肪干细胞在软骨组织工程中的研究进展

doi:10.3969/j.issn.0258-8021. 2014. 04.012

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Abstract The potential for adiposederived stem cells (ADSCs) of differentiating into chondrocytes has attracted increasing attentions in recent years. As seed cells, ADSCs have broad prospects in the use of cartilage tissue engineering. However, methods to obtain high quality cells are still lack and have
not been recognized in the world. Although various methods such as exogenous growth factors, genetic modification, coculture, growth factors ally with coculture, and scaffold materials can induce the differentiation of ADSCs into chondrocytes, the pros and cons of each method, signaling pathways of differentiation and traits of neochondrocytes are not clear in detail. This paper introduced the status and problems of multiple methods mentioned above, and discussed the influence of the chemical factors, donor age, organizations to get parts etc. on the cell culture, aiming to provide a theoretical reference for the clinical application of ADSCs.

Key words： cartilage tissue engineering adipose derived stem cells growth factors coculture scaffold materials

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	ZHAO Ming Can LIU Chang^*

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ZHAO Ming Can LIU Chang^*. Research Progress on AdiposeDerived Stem Cells in Cartilage Tissue Engineering[J]. journal1, 2014, 33(4): 475-481.

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http://cjbme.csbme.org/EN/10.3969/j.issn.0258-8021. 2014. 04.012 OR http://cjbme.csbme.org/EN/Y2014/V33/I4/475