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Study on TEMPO-mediated Oxidation of Bacterial Cellulose |
1 School of Information & Engineering, Wenzhou Medical University, Wenzhou 325035, China
2 Biomedical Engineering Research Center, Shenzhen Institute of Peking University, Shenzhen 518057, China
3 School of Life Science, Anhui University, Hefei 230601, China
4 School of Laboratory Medicine & Life Science, Wenzhou Medical University, Wenzhou 325035, China |
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Abstract Bacterial cellulose (BC) is a kind of biomedical scaffold with nano network, and its biodegradation can be improved through selective catalytic oxidation. The TEMPO-mediated oxidation of BC was investigated when the amount of NaClO, TEMPO and the reaction time changed. The experimental results reveal that, in the range of test conditions, the initial reaction rate is inversely proportional to the amount of NaClO; the pH of system is one of the main factors which influence this stage reaction rate, and the maximum reaction rate appears in pH=10.50~11.00; while the amount of TEMPO has no obvious effect on it. For the whole reaction process, both the reaction rate and waterinsoluble fractions' carboxylic content are proportional to the amount of NaClO, and they have a good linear relationship when the dosage of 0.6 mol/L NaClO is during 1~8 mL; both of them are also proportional to the amount of TEMPO. The waterinsoluble fractions' carboxylic content gradually decreases at first and then remains stable at 0.70~0.75 mol/kg with increasing oxidation time. In conclusion, the rule of the TEMPO-mediated oxidation of BC has significant differences in different stages, and the main cause could be its unique nanostructure and properties.
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