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The Technologies and Perspectives of Anticoagulant Coating |
Lei Shaojin1, Zheng Yi2, Shi Jie2,3, Dong Yunsheng1, Wang Shufang1#* |
1(Key Laboratory of Bioactive Materials, Ministry of Education, College of Life Sciences, Nankai University, Tianjin 300071, China) 2(Wenzhou Safety (Emergency) Institute,Tianjin University,Wenzhou 325000, Zhejiang, China) 3(Institute of Disaster and Emergency Medicine, Tianjin University, Tianjin 300072, China) |
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Abstract With acceleration of population aging and urbanization, the number of patients with cardiovascular diseases has gradually increased. Development of cardiovascular implantable devices have attracted increasing attentions in recent years. The high risk of thrombosis is a major factor limiting the application of cardiovascular implanted devices, that is why it is so important to construct anticoagulant coatings on the surface of cardiovascular implanted devices. In this review, we summarized the research progress of anticoagulant coating construction methods in both domestic and foreign researches, analyzed and discussed the conventional and latest anticoagulation strategies from the aspects of physical, chemical and biological methods. Existing problems and prospects of anticoagulation coating construction were also discussed.
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Received: 14 November 2022
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Corresponding Authors:
* E-mail: wangshufang@nankai.edu.cn
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About author:: #Senior member, Chinese Society of Biomedical Engineering |
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