Research Progress of Nanomaterial Targeted Drug Delivery in Osteoarthritis Treatment
Zhang Yingyu1, Zhao Linlin1,2, Li Liangxiao3, Liu Yingying1,3*, Liu Yajun1,4*
1(Science and Technology Innovation Center, Shandong First Medical University & Shandong Academy of Medical Sciences, Jinan 250117,China) 2(School of Public Health, Shandong First Medical University & Shandong Academy of Medical Sciences, Jinan 250117, China) 3(Medical Science and Technology Innovation Center, Shandong First Medical University & Shandong Academy of Medical Sciences, Jinan 250117, China) 4(Beijing Jishuitan Hospital Affiliated to Capital Medical University, Beijing Research Institute of Traumatology and Orthopedics, Beijing 100035, China)
Abstract Osteoarthritis is a chronic, highly prevalent degenerative disease. Delivering drugs to the joints presents challenges, as free drugs injected into the joints are prone to degradation and rapid clearance through the lymphatic and blood systems. Nano-targeted drug delivery systems, designed with specific assembly and appearance modifications, offer significant advantages. They can increase the drug concentration at the arthritic site, improve efficacy, reduce toxicity, therefore, have been extensively studied for uses in osteoarthritis treatment. This review introduced current nano-drug delivery strategies that featured active targeting in treating osteoarthritis, summarized research work on nano-drug delivery systems enhanced by biotargeting ligands and biomimetic biofilms, highlighting their advantages and limitations. In addition, we discussed the potential future developments of nano-drug delivery systems, aiming to provide references and constructive suggestions for improving the past active targeting and modification strategies of nanomaterials.
Zhang Yingyu,Zhao Linlin,Li Liangxiao, et al. Research Progress of Nanomaterial Targeted Drug Delivery in Osteoarthritis Treatment[J]. Chinese Journal of Biomedical Engineering, 2024, 43(3): 369-376.
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