1Zhongnan Hospital of Wuhan University, Department of Medical Imaging, Wuhan 430070, China 2Department of Ultrasound, Union Hospital, Tongji Medical College, Huazhong Universtiy of Science and Technology, Wuhan 430070, China
Abstract：The selection of reference image is one of the key roles for the efficiency of respiratory motion correction method based on liver contrast-enhance ultrasound (CEUS) image sequences. The selection method is worthwhile exploring. First, the original high-dimensional ultrasound data was mapped into a two-dimensional space by using Laplacian eigenmaps. Then, the cluster analysis was adopted using k-means, and the optimal ultrasound reference image was obtained for the respiratory motion correction. Finally, the effectiveness of this proposed method was validated with 18 CEUS cases of VX2 tumor implanted in the rabbit liver. Before correction, the average of total mean structural similarity and the average of mean correlation coefficient from image sequences were 0.45±0.11 and 0.67±0.16,respectively. After correction, the two parameters were increased obviously (P<0.001) as 0.59±0.11 and 0.81±0.11 respectively. The average of deviation valve (DV) from image sequences before correction was 92.16±18.12. After correction, the average of DV was reduced to one-third of the original value. The proposed respiratory motion method improved the accuracy of the quantitative analysis of CEUS by using the reference image based on the traditionally manual selection as well as operated simply, therefore is of potentials in the clinical application.
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