医学超声造影成像的新技术研究进展

doi:10.3969/j.issn.0258-8021. 2016. 02.014

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摘要鉴于其无创实时及较高的确诊率，超声造影成像在癌症诊断中扮演着愈发重要的角色。其中，如何提高造影信号强度、持续时间与图像质量，是工程界最为关注的要点。因此，全面总结近年来国内外在超声造影成像工程技术领域的最新进展，主要包括4个方面：一是基于弱衰减性低频回波检测，进而具有更高信噪比和造影组织比率的新型非线性成像方法——次谐波造影成像；二是能够提升图像时间分辨率以及降低微泡击碎程度/延长持续时间的平面波造影技术；三是旨在提升造影图像穿透力的编码发射技术；四是针对超高频造影应用场合的新型造影剂研究。

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	章希睿¹
	3张明博²桑茂栋¹王广志^3*唐杰²

关键词 ：超声造影, 次谐波, 平面波, 编码发射, 新型造影剂

Abstract：Due to its characteristics of noninvasive, real-time, and high diagnosis ratios, contrast-enhanced ultrasound imaging has played an increasingly important role in cancer diagnosis. Herein, the latest research progress of contrast-enhanced ultrasound imaging was summarized in this paper, mainly including following aspects: 1) Subharmonic ultrasound imaging with a higher contrast-to-tissue ratio and superior penetration performance, which are due to detection of the lower frequency component of the microbubbles′ backscatter echoes; 2) Application of plane-wave emission technology in ultrasound contrast imaging that is capable of increasing temporal resolution whilst reducing microbubble′s destruction; 3) Coded excitation based ultrasound contrast imaging to obtain a better penetration; 4) Experimental research on new types of ultrasound contrast agents for ultrahigh frequency imaging.

Key words： contrast-enhanced ultrasound plane-wave subharmonic coded excitation new ultrasound contrast agent

基金资助:国家自然科学基金专项基金（81327003）；国家自然科学基金（81471759，81271735）

引用本文:

章希睿^{1, 3}张明博²桑茂栋¹王广志^3*唐杰²
. 医学超声造影成像的新技术研究进展[J]. 中国生物医学工程学报, 2016, 35(2): 225-233.
Zhang Xirui^{1, 3}Zhang Mingbo²Sang Maodong¹Wang Guangzhi^3*Tang Jie^2
. Review on State-of-the-Art of Contrast-Enhanced Ultrasound Imaging. journal1, 2016, 35(2): 225-233.

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http://cjbme.csbme.org/CN/10.3969/j.issn.0258-8021. 2016. 02.014 或 http://cjbme.csbme.org/CN/Y2016/V35/I2/225

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