The Neuroimage Research Progress of Psychiatric Comorbidities in Epilepsy
He Zhongqiong1, Yu Liang2, Jiang Yuchao1, BenjaminKlugah-Brown1, Luo Cheng1*, Yao Dezhong1#
1(Center for Information in Medicine. Key Laboratory for NeuroInformation of Ministry of Education,School of Life Science and Technology, University of Electronic Science and Technology of China,Chengdu 610054,China) 2(Affiliated Hospital of University of Electronic Science and Technology of China·Sichuan Provincial People’s Hospital, Department of Neurology, Chengdu 610072, China)
Abstract：Psychiatric comorbidities in epilepsy is a common mental disorder, but the mechanisms of those disorders are indefinite, and some patients are disturbed by this disease time and again, which greatly affects the quality of life in patients. The technologies of neuroimaging provide a unique approach to studying the abnormal cerebral structure and function. This article is to review recent studies of psychiatric comorbidities in epilepsy based on depression in people with epilepsy, anxiety in people with epilepsy, schizophrenia-like psychosis of epilepsy and attention deficit- hyperactivity disorder (ADHD) in people with epilepsy, aiming to expand the way of thinking about and understanding in clinical researches and in exploring mechanisms of psychosis of epilepsy.
何忠琼, 喻 良, 蒋宇超, Benjamin Klugah-Brown, 罗 程, 尧德中. 癫痫合并精神障碍神经影像学的研究进展[J]. 中国生物医学工程学报, 2017, 36(3): 342-347.
He Zhongqiong, Yu Liang, Jiang Yuchao, BenjaminKlugah-Brown, Luo Cheng, Yao Dezhong. The Neuroimage Research Progress of Psychiatric Comorbidities in Epilepsy. Chinese Journal of Biomedical Engineering, 2017, 36(3): 342-347.
[1] Garcia-Morales I, de la Pena Mayor P, Kanner AM. Psychiatric comorbidities in epilepsy: identification and treatment [J]. Neurologist, 2008, 14(6 Suppl 1): S15-S25. [2] 尧德中,罗程,雷旭,等. 中国生物医学工程学报 [J]. 脑成像与脑连接, 2011, 30(1): 6-10. [3] Dong Li, Luo Cheng, Cao Weifang, et al. Spatiotemporal consistency of local neural activities: A new imaging measure for functional MRI data [J]. J Magn Reson Imaging, 2015, 42(3): 729-736. [4] 陈哲萌,丁美萍. 癫痫与抑郁共病的研究进展 [J]. 现代实用医学, 2014, 26(12): 1465-1467. [5] Kanner AM. Depression and epilepsy: a review of multiple facets of their close relation [J]. Neurol Clin, 2009, 27(4): 865-880. [6] Quiske A, Helmstaedter C, Lux S, et al. Depression in patients with temporal lobe epilepsy is related to mesial temporal sclerosis [J]. Epilepsy Res, 2000, 39(2): 121-125. [7] Frodl T, Meisenzahl EM, Zetzsche T, et al. Hippocampal changes in patients with a first episode of major depression [J]. Am J Psychiatry, 2002, 159(7): 1112-1118. [8] Finegersh A, Avedissian C, Shamim S, et al. Bilateral hippocampal atrophy in temporal lobe epilepsy: effect of depressive symptoms and febrile seizures [J]. Epilepsia, 2011, 52(4): 689-697. [9] Shamim S, Hasler G, Liew C, et al. Temporal lobe epilepsy, depression, and hippocampal volume [J]. Epilepsia, 2009, 50(5): 1067-1071. [10] Hecimovic H, Santos J, Price JL, et al. Severe hippocampal atrophy is not associated with depression in temporal lobe epilepsy [J]. Epilepsy Behav, 2014, 34(5): 9-14. [11] Kanner AM, Schachter SC, Barry JJ, et al. Depression and epilepsy: epidemiologic and neurobiologic perspectives that may explain their high comorbid occurrence [J]. Epilepsy Behav, 2012, 24(2): 156-168. [12] Richardson EJ, Griffith HR, Martin RC, et al. Structural and functional neuroimaging correlates of depression in temporal lobe epilepsy [J]. Epilepsy Behav, 2007, 10(2): 242-249. [13] Tebartz van Elst L, Woermann F, Lemieux L, et al. Increased amygdala volumes in female and depressed humans. A quantitative magnetic resonance imaging study [J]. Neurosci Lett, 2000, 281(2-3): 103-106. [14] Frodl T, Meisenzahl E, Zetzsche T, et al. Enlargement of the amygdala in patients with a first episode of major depression [J]. Biol Psychiatry, 2002, 51(9): 708-714. [15] Drevets WC, Videen TO, Price JL, et al. A functional anatomical study of unipolar depression [J]. J Neurosci, 1992, 12(9): 3628-3641. [16] Sapolsky RM. Glucocorticoids and hippocampal atrophy in neuropsychiatric disorders [J]. Arch Gen Psychiatry, 2000, 57(10): 925-935. [17] Lin JJ, Salamon N, Lee AD, et al. Reduced neocortical thickness and complexity mapped in mesial temporal lobe epilepsy with hippocampal sclerosis [J]. Cereb Cortex, 2007, 17(9): 2007-2018. [18] Bernhardt BC, Bernasconi N, Concha L, et al. Cortical thickness analysis in temporal lobe epilepsy: reproducibility and relation to outcome [J]. Neurology, 2010, 74(22): 1776-1784. [19] Pope RA, Centeno M, Flugel D, et al. Neural correlates of de novo depression following left temporal lobe epilepsy surgery: a voxel based morphometry study of pre-surgical structural MRI [J]. Epilepsy Res, 2014, 108(3): 517-525. [20] Bromfield EB, Altshuler L, Leiderman DB, et al. Cerebral metabolism and depression in patients with complex partial seizures [J]. Arch Neurol, 1992, 49(6): 617-623. [21] Gilliam FG, Santos J, Vahle V, et al. Depression in epilepsy: ignoring clinical expression of neuronal network dysfunction? [J]. Epilepsia, 2004, 45(Suppl S2): 28-33. [22] Salzberg M, Taher T, Davie M, et al. Depression in temporal lobe epilepsy surgery patients: an FDG-PET study [J]. Epilepsia, 2006, 47(12): 2125-2130. [23] McRae K, Hughes B, Chopra S, et al. The neural bases of distraction and reappraisal [J]. J Cogn Neurosci, 2010, 22(2): 248-262. [24] Mayberg HS. Positron emission tomography imaging in depression: a neural systems perspective [J]. Neuroimaging Clin N Am, 2003, 13(4): 805-815. [25] Hasler G, Bonwetsch R, Giovacchini G, et al. 5-HT1A receptor binding in temporal lobe epilepsy patients with and without major depression [J]. Biol Psychiatry, 2007, 62(11): 1258-1264. [26] Victoroff JI, Benson F, Grafton ST, et al. Depression in complex partial seizures. Electroencephalography and cerebral metabolic correlates [J]. Arch Neurol, 1994, 51(2): 155-163. [27] Chen Sihan, Wu Xintong, Lui Su, et al. Resting-state fMRI study of treatment-naive temporal lobe epilepsy patients with depressive symptoms [J]. Neuroimage, 2012, 60(1): 299-304. [28] 佟晓燕, 王玉平. 成年癫痫患者抑郁、焦虑状况及生活质量调查 [J]. 脑与神经疾病杂志, 2009, 17(2): 123-126. [29] Kwon OY, Park SP. Depression and anxiety in people with epilepsy [J]. J Clin Neurol, 2014, 10(3): 175-188. [30] Kanner AM. Anxiety disorders in epilepsy: the forgotten psychiatric comorbidity [J]. Epilepsy Curr, 2011, 11(3): 90-91. [31] Satishchandra P, Krishnamoorthy ES, van Elst LT, et al. Mesial temporal structures and comorbid anxiety in refractory partial epilepsy [J]. J Neuropsychiatry Clin Neurosci, 2003, 15(4): 450-452. [32] Chapouthier G, Venault P. A pharmacological link between epilepsy and anxiety? [J]. Trends Pharmacol Sci, 2001, 22(10): 491-493. [33] 刘志强, 古训瑚, 徐丽君. 杏仁核在焦虑症中的作用研究进展 [J]. 实用医学杂志, 2014, 30(19): 3180-3182. [34] Biraben A, Taussig D, Thomas P, et al. Fear as the main feature of epileptic seizures [J]. J Neurol Neurosurg Psychiatry, 2001, 70(2): 186-191. [35] Etkin A, Prater KE, Hoeft F, et al. Failure of anterior cingulate activation and connectivity with the amygdala during implicit regulation of emotional processing in generalized anxiety disorder [J]. Am J Psychiatry, 2010, 167(5): 545-554. [36] Nitschke JB, Sarinopoulos I, Oathes DJ, et al. Anticipatory activation in the amygdala and anterior cingulate in generalized anxiety disorder and prediction of treatment response [J]. Am J Psychiatry, 2009, 166(3): 302-310. [37] Milad MR, Rauch SL. The role of the orbitofrontal cortex in anxiety disorders [J]. Ann N Y Acad Sci, 2007, 1121(1): 546-561. [38] Vermetten E, Schmahl C, Southwick SM, et al. Positron tomographic emission study of olfactory induced emotional recall in veterans with and without combat-related posttraumatic stress disorder [J]. Psychopharmacol Bull, 2007, 40(1): 8-30. [39] Heersink M, Kocovski NL, MacKenzie MB, et al. Social anxiety and its psychosocial impact on the lives of people with epilepsy [J]. Epilepsy Behav, 2015, 51(10): 286-293. [40] Brown FC, Westerveld M, Langfitt JT, et al. Influence of anxiety on memory performance in temporal lobe epilepsy [J]. Epilepsy Behav, 2014, 31(2): 19-24. [41] Jones JE. Treating anxiety disorders in children and adolescents with epilepsy: what do we know? [J]. Epilepsy Behav, 2014, 39(10): 137-142. [42] Mula M. Treatment of anxiety disorders in epilepsy: an evidence-based approach [J]. Epilepsia, 2013, 54 (Suppl 1): 13-18. [43] Canuet L, Ishii R, Pascual-Marqui RD, et al. Resting-state EEG source localization and functional connectivity in schizophrenia-like psychosis of epilepsy [J]. PLoS ONE, 2011, 6(11): 905-905. [44] Canuet L, Ishii R, Iwase M, et al. Psychopathology and working memory-induced activation of the prefrontal cortex in schizophrenia-like psychosis of epilepsy: Evidence from magnetoencephalography [J]. Psychiatry Clin Neurosci, 2011, 65(2): 183-190. [45] Butler T, Weisholtz D, Isenberg N, et al. Neuroimaging of frontal-limbic dysfunction in schizophrenia and epilepsy-related psychosis: toward a convergent neurobiology [J]. Epilepsy Behav, 2012, 23(2): 113-122. [46] Chang Yu-Tzu, Chen Peichun, Tsai IJ, et al. Bidirectional relation between schizophrenia and epilepsy: a population-based retrospective cohort study [J]. Epilepsia, 2011, 52(11): 2036-2042. [47] Maier M, Mellers J, Toone B, et al. Schizophrenia, temporal lobe epilepsy and psychosis: an in vivo magnetic resonance spectroscopy and imaging study of the hippocampus/amygdala complex [J]. Psychol Med, 2000, 30(3): 571-581. [48] Marchetti RL, Azevedo D Jr, de Campos Bottino CM, et al. Volumetric evidence of a left laterality effect in epileptic psychosis [J]. Epilepsy Behav, 2003, 4(3): 234-240. [49] Rusch N, Tebartz van Elst L, Baeumer D, et al. Absence of cortical gray matter abnormalities in psychosis of epilepsy: a voxel-based MRI study in patients with temporal lobe epilepsy [J]. J Neuropsychiatry Clin Neurosci, 2004, 16(2): 148-155. [50] Tebartz Van Elst L, Baeumer D, Lemieux L, et al. Amygdala pathology in psychosis of epilepsy: A magnetic resonance imaging study in patients with temporal lobe epilepsy [J]. Brain, 2002, 125(Pt 1): 140-149. [51] Mellers JD, Adachi N, Takei N, et al. SPET study of verbal fluency in schizophrenia and epilepsy [J]. Br J Psychiatry, 1998, 173(1): 69-74. [52] Koneski JA, Casella EB. Attention deficit and hyperactivity disorder in people with epilepsy: diagnosis and implications to the treatment [J]. Arq Neuropsiquiatr, 2010, 68(1): 107-114. [53] Mackie S, Shaw P, Lenroot R, et al. Cerebellar development and clinical outcome in attention deficit hyperactivity disorder [J]. Am J Psychiatry, 2007, 164(4): 647-655. [54] Hermann B, Jones J, Dabbs K, et al. The frequency, complications and aetiology of ADHD in new onset paediatric epilepsy [J]. Brain, 2007, 130(Pt 12): 3135-3148. [55] Kim BN, Kim JW, Kang H, et al. Regional differences in cerebral perfusion associated with the alpha-2A-adrenergic receptor genotypes in attention deficit hyperactivity disorder [J]. J Psychiatry Neurosci, 2010, 35(5): 330-336. [56] 刘璐, 周农. 成人癫痫患者合并注意缺陷多动障碍的临床研究 [J]. 中华神经科杂志, 2015, 48(12): 1052-1056.
