Research Progress on Melanoma Postoperative Hydrogel Therapy Platform
Li Jinhua1, Sun Honggang2*
1(Department of Oncology, The First People′s Hospital of Jinzhong, Jinzhong 030600, Shanxi, China) 2(Southwest Institute of Technology and Engineering, Chongqing 400039, China)
Abstract：Melanoma has remarkably gained extensive attention owing to its high morbidity and mortality. Surgical resection is the mainstay for melanoma therapy in clinic. Inhibiting the recurrence of melanoma and healing after-surgical wounds have been great challenges in clinical studies. Hydrogels is a class of three-dimensional network of biomaterials with unique porous structures, and hydrogel therapy platforms can offer solutions to these challenges. In this review, we summarized recent developments of polymer-based hydrogels as therapy platforms for local delivery of therapeutic agents for postoperative melanoma therapy. According to the mechanisms that induce cancer cell death in melanoma, we focused on the latest research achievements of hydrogel chemotherapy, photodynamic therapy (PDT), photothermal therapy (PTT), immunotherapy, and combination therapies. Furthermore, the merits of postoperative therapy platform of the hydrogels were summarized and existing challenges and further perspectives of this platform for melanoma postoperative therapy were discussed.
李晋华, 孙宏刚. 黑色素瘤术后水凝胶治疗平台的研究进展[J]. 中国生物医学工程学报, 2025, 44(5): 622-630.
Li Jinhua, Sun Honggang. Research Progress on Melanoma Postoperative Hydrogel Therapy Platform. Chinese Journal of Biomedical Engineering, 2025, 44(5): 622-630.
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