Study on the Selection and Fatigue Performance of Porous Bone Scaffolds Fabricated by ElectronBeam Melting
Xie Haiqiong1,2, Gan Daoqi1, Liu Fei1,2*, Xie Haitao3, Yang Baiyin1, Zhou Tianyu1
1(School of Advanced Manufacturing Engineering, Chongqing University of Posts and Telecommunications, Chongqing 400065, China) 2(Sports Medicine Center, The First Affiliated Hospital of Army Medical University, Chongqing 400037, China) 3(Orthopaedic Department, Ganzhou Xingguo People′s Hospital, Ganzhou 342400, Jiangxi, China)
Abstract：Additive manufactured porous structure offers excellent mechanical biomimicry and osseointegration properties, supporting long-term stability of orthopedic implants in human body. This study employed triply periodic minimal surfaces (TPMS) method and Electron Beam Melting (EBM) technology to design and fabricate porous bone mimicking scaffolds. By investigating the pore characteristics, mechanical performance and fatigue life, a novel selection method suitable for bone implantable devices was proposed to meet the requirements of porosity connectivity, mechanical stability, and high-cycle fatigue life. Micro-CT and SEM characterization revealed the porous scaffolds with unit cell sizes ≥1.5 mm had biomimetic pore sizes (748 μm) and good pore connectivity. The mechanical stability and reliability of TPMS-Gyroid scaffolds were superior to TPMS-Diamond. The established Gibson-Ashby equation in this work provided mechanical performance prediction for titanium alloy porous scaffolds. The fatigue life of the scaffolds exceeded 106 cycles at a stress level of 0.2, satisfying the long-term safety requirements for implant materials, with an elastic modulus similar to that of human cancellous bone (0.1~1.1 GPa). Furthermore, fatigue behavior studies also indicated that fatigue ratchet and fatigue damage were main causes of porous scaffold failure. In the design of metal porous scaffold’s structure, the number of cracks could be reduced by increasing the size of the scaffold unit cell, which was helpful to improve the fatigue life of the scaffolds.
谢海琼, 甘道其, 刘飞, 谢海涛, 杨白银, 周天宇. 电子束增材制造多孔骨支架的选用与疲劳性能研究[J]. 中国生物医学工程学报, 2024, 43(3): 348-357.
Xie Haiqiong, Gan Daoqi, Liu Fei, Xie Haitao, Yang Baiyin, Zhou Tianyu. Study on the Selection and Fatigue Performance of Porous Bone Scaffolds Fabricated by ElectronBeam Melting. Chinese Journal of Biomedical Engineering, 2024, 43(3): 348-357.
[1] 屈华伟,韩振宇,卓越,等. 骨组织工程多孔生物支架设计研究进展[J]. 机械工程学报,2019,55(15): 71-80. [2] 甄珍,王健,奚廷斐,等. 3D打印钛金属骨科植入物应用现状[J]. 中国生物医学工程学报,2019,38(2): 240-251. [3] She Zhizhong, Nie Yan, Zhong Hui, et al. Effect of surface deformation on biocompatibility of biomedical alloys[J]. Materials Science & Engineering C, 2021, 119(11): 1-11. [4] Saheb SH, Durgam VK, Chandrashekhar A, et al. A review on metal powders in additive manufacturing[J]. 2020, 2281(2): 1-8. [5] Murr LE. Metallurgy principles applied to powder bed fusion 3D printing/additive manufacturing of personalized and optimized metal and alloy biomedical implants: an overview[J]. Journal of Materials Research and Technology, 2020, 9(1): 1087-1103. [6] Luo Changqi, Wang C, Xiangdong, et al. Influence of porous tantalum scaffold pore size on osteogenesis and osteointegration: a comprehensive study based on 3D-printing technology[J]. Materials Science & Engineering C, 2021, 129(11): 1-14. [7] Xiong Yinze, Wang Wei, Gao Ruining, et al. Fatigue behavior and osseointegration of porous Ti-6Al-4V scaffolds with dense core for dental application[J]. Materials & Design, 2020, 195(10): 1-16. [8] Huo Pengcheng, Zhao Zhanyong, Bai Peikang, et al. Deformation evolution and fracture mechanism of porous TC4 alloy scaffolds fabricated using selective laser melting under uniaxial compression[J]. Journal of Alloys and Compounds, 2021, 861(15): 1-11. [9] 焦程,晁龙,朱磊,等. 面向骨科植入物的仿生多孔结构设计制造方法研究[J]. 中国机械工程,2021,42: 1-8. [10] Liu Fei, Gan Daoqi, Zhang Kaifei, et al. A selective strategy for determining suitable structure and fatigue behavior study of minimal surface scaffolds fabricated by EBM[J]. International Journal of Fatigue, 2023, 167: 107380. [11] Lashgari HR, Ferry M, Li S, et al. Additive manufacturing of bulk metallic glasses: Fundamental principle, current/future developments and applications[J]. Journal of Materials Science & Technology, 2022, 119(20): 131-149. [12] Xu Wei. Direct additive manufacturing techniques for metal parts: slm, ebm, laser metal deposition[J]. Encyclopedia of Materials:Metals and Alloys, 2022, 3(25): 290-318. [13] Song K, Wang Zhaohui, Lan Jing, et al. Porous structure design and mechanical behavior analysis based on TPMS for customized root analogue implant[J]. Journal of the Mechanical Behavior of Biomedical Materials, 2021, 115(10): 1-9. [14] Xiong Yinze, Han Zhengzhe, Qin Jiawei, et al. Effects of porosity gradient pattern on mechanical performance of additive manufactured Ti-6Al-4V functionally graded porous structure[J]. Materials & Design, 2021, 208(10): 1-18. [15] Cheng XY, Li SJ, Murr LE, et al. Compression deformation behavior of Ti-6Al-4V alloy with cellular structures fabricated by electron beam melting[J]. Journal of the Mechanical Behavior of Biomedical Materials, 2012, 16(10): 153-162. [16] Ren Bo, Liu Jingjing, Wang Yali, et al. Highly porous and hierarchical MgAl2O4 ceramics with improved pore connectivity prepared from gelled particle-stabilized foams[J]. Ceramics International, 2019, 45(14): 17489-17494. [17] Liu Fei, Mao Zhongfa, Zhang Peng, et al. Functionally graded porous scaffolds in multiple patterns: New design method, physical and mechanical properties[J]. Materials & Design, 2018, 160(15): 849-860. [18] Zhao Shuo, Li Shujun, Wang Shaogang, et al. Compressive and fatigue behavior of functionally graded Ti-6Al-4V meshes fabricated by electron beam melting[J]. Acta Materialia, 2018, 150(15): 1-15. [19] Wang Yue, Liu Fei, Zhang Xinyue, et al. Cell-size graded sandwich enhances additive manufacturing fidelity and energy absorption[J]. International Journal of Mechanical Sciences, 2021, 211(10): 1-14. [20] Novak N, Al-Ketan O, Borovinšek M, et al. Development of novel hybrid TPMS cellular lattices and their mechanical characterisation[J]. Journal of Materials Research and Technology, 2021, 15(92): 1318-1329. [21] Yang Lei, Yan Chunze, Cao Wenchao, et al. Compression-compression fatigue behaviour of gyroid-type triply periodic minimal surface porous structures fabricated by selective laser melting[J]. Acta Materialia, 2019, 181(5): 49-66. [22] Zadpoor A. Bone tissue regeneration: the role of scaffold geometry[J]. Biomaterials Science, 2015, 3(2): 231-245. [23] Alvarez K, Nakajima H. Metallic scaffolds for bone regeneration[J]. Materials, 2009, 2(3): 790-832. [24] Karageorgiou V, Kaplan D. Porosity of 3D biomaterial scaffolds and osteogenesis[J]. Biomaterials, 2005, 26(27): 5474-5491. [25] Rohlman A, Zilch H, Bergmann G, et al. Material properties of femoral cancellous bone in axial loading Part I: time independent properties[J]. Archives of Orthopaedic and Traumatic Surgery, 1980, 97(2): 95-102. [26] Zhou J, Soboyejo WO. Compression-compression fatigue of open cell aluminum foams: macro-/micro- mechanisms and the effects of heat treatment[J]. Materials Science and Engineering: A, 2004, 369(1-2): 23-35. [27] Li Shujun, Murr LE, Cheng Xuying, et al. Compression fatigue behavior of Ti-6Al-4V mesh arrays fabricated by electron beam melting[J]. Acta Materialia, 2012, 60(3): 793-802. [28] M. F. Ashby, Mehl Medalist.R.F, The mechanical properties of cellular solids[J], Metallurgical Transactions A ,1983,14:1755-1769. [29] Ma Zhibo, Zhang D, Liu Fei, et al. Lattice structures of Cu-Cr-Zr copper alloy by selective laser melting: Microstructures, mechanical properties and energy absorption[J]. Materials & Design, 2020, 187(10): 1-12. [30] Zhang Lei, Feih S, Daynes S, et al. Energy absorption characteristics of metallic triply periodic minimal surface sheet structures under compressive loading[J]. Additive Manufacturing, 2018, 23(47): 505-515. [31] Yan Chunze, Hao Liang, Hussein A, et al. Evaluations of cellular lattice structures manufactured using selective laser melting[J]. International Journal of Machine Tools and Manufacture, 2012, 62(4): 32-38. [32] Liu Yajun, Wang Hongliang, Li Shujun, et al. Compressive and fatigue behavior of beta-type titanium porous structures fabricated by electron beam melting[J]. Acta Materialia, 2017, 126(6): 58-66. [33] Liu YJ, Ren DC, Li SJ, et al. Enhanced fatigue characteristics of a topology-optimized porous titanium structure produced by selective laser melting[J]. Additive Manufacturing, 2020, 32(10): 1-25. [34] Guo Yu, Chen Chao, Tan Liming, et al. The role of pore structures on the fatigue properties of additively manufactured porous tantalum scaffolds produced by electron beam powder bed fusion[J]. Journal of Materials Research and Technology, 2022, 19(126): 3461-3473.
